Shady Rahayel1, Ronald B Postuma1, Jacques Montplaisir1, Daphné Génier Marchand1, Frédérique Escudier1, Malo Gaubert1, Pierre-Alexandre Bourgouin1, Julie Carrier1, Oury Monchi1, Sven Joubert1, Frédéric Blanc1, Jean-François Gagnon2. 1. From the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France. 2. From the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France. gagnon.jean-francois.2@uqam.ca.
Abstract
OBJECTIVE: To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI). METHODS: Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images. Vertex-based cortical analyses of volume, thickness, and surface area were performed to investigate cortical abnormalities between groups, whereas vertex-based shape analysis was performed to investigate subcortical structure surfaces. Correlations were performed to investigate associations between cortical and subcortical metrics, cognitive domains, and other markers of neurodegeneration (color discrimination, olfaction, and autonomic measures). RESULTS: Patients with MCI had cortical thinning in the frontal, cingulate, temporal, and occipital cortices, and abnormal surface contraction in the lenticular nucleus and thalamus. Patients without MCI had cortical thinning restricted to the frontal cortex. Lower patient performance in cognitive domains was associated with cortical and subcortical abnormalities. Moreover, impaired performance on olfaction, color discrimination, and autonomic measures was associated with thinning in the occipital lobe. CONCLUSIONS: Cortical and subcortical gray matter abnormalities are associated with cognitive status in patients with RBD, with more extensive patterns in patients with MCI. Our results highlight the importance of distinguishing between subgroups of patients with RBD according to cognitive status in order to better understand the neurodegenerative process in this population.
OBJECTIVE: To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI). METHODS: Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images. Vertex-based cortical analyses of volume, thickness, and surface area were performed to investigate cortical abnormalities between groups, whereas vertex-based shape analysis was performed to investigate subcortical structure surfaces. Correlations were performed to investigate associations between cortical and subcortical metrics, cognitive domains, and other markers of neurodegeneration (color discrimination, olfaction, and autonomic measures). RESULTS:Patients with MCI had cortical thinning in the frontal, cingulate, temporal, and occipital cortices, and abnormal surface contraction in the lenticular nucleus and thalamus. Patients without MCI had cortical thinning restricted to the frontal cortex. Lower patient performance in cognitive domains was associated with cortical and subcortical abnormalities. Moreover, impaired performance on olfaction, color discrimination, and autonomic measures was associated with thinning in the occipital lobe. CONCLUSIONS: Cortical and subcortical gray matter abnormalities are associated with cognitive status in patients with RBD, with more extensive patterns in patients with MCI. Our results highlight the importance of distinguishing between subgroups of patients with RBD according to cognitive status in order to better understand the neurodegenerative process in this population.
Authors: Frederic Blanc; Sean J Colloby; Nathalie Philippi; Xavier de Pétigny; Barbara Jung; Catherine Demuynck; Clélie Phillipps; Pierre Anthony; Alan Thomas; Fabrice Bing; Julien Lamy; Catherine Martin-Hunyadi; John T O'Brien; Benjamin Cretin; Ian McKeith; Jean-Paul Armspach; John-Paul Taylor Journal: PLoS One Date: 2015-06-10 Impact factor: 3.240
Authors: Alex Iranzo; Ana Fernández-Arcos; Eduard Tolosa; Mónica Serradell; José Luis Molinuevo; Francesc Valldeoriola; Ellen Gelpi; Isabel Vilaseca; Raquel Sánchez-Valle; Albert Lladó; Carles Gaig; Joan Santamaría Journal: PLoS One Date: 2014-02-26 Impact factor: 3.240
Authors: Shady Rahayel; Malo Gaubert; Ronald B Postuma; Jacques Montplaisir; Julie Carrier; Oury Monchi; David Rémillard-Pelchat; Pierre-Alexandre Bourgouin; Michel Panisset; Sylvain Chouinard; Sven Joubert; Jean-François Gagnon Journal: Sleep Date: 2019-06-11 Impact factor: 5.849
Authors: Trina Mitchell; Stéphane Lehéricy; Shannon Y Chiu; Antonio P Strafella; A Jon Stoessl; David E Vaillancourt Journal: JAMA Neurol Date: 2021-10-01 Impact factor: 29.907
Authors: Mitchell G Miglis; Charles H Adler; Elena Antelmi; Dario Arnaldi; Luca Baldelli; Bradley F Boeve; Matteo Cesari; Irene Dall'Antonia; Nico J Diederich; Kathrin Doppler; Petr Dušek; Raffaele Ferri; Jean-François Gagnon; Ziv Gan-Or; Wiebke Hermann; Birgit Högl; Michele T Hu; Alex Iranzo; Annette Janzen; Anastasia Kuzkina; Jee-Young Lee; Klaus L Leenders; Simon J G Lewis; Claudio Liguori; Jun Liu; Christine Lo; Kaylena A Ehgoetz Martens; Jiri Nepozitek; Giuseppe Plazzi; Federica Provini; Monica Puligheddu; Michal Rolinski; Jan Rusz; Ambra Stefani; Rebekah L S Summers; Dallah Yoo; Jennifer Zitser; Wolfgang H Oertel Journal: Lancet Neurol Date: 2021-08 Impact factor: 44.182