Pietro Mattioli1,2, Matteo Pardini3,4, Francesco Famà3,4, Nicola Girtler3,4, Andrea Brugnolo3,4, Beatrice Orso3, Riccardo Meli3,4, Laura Filippi3,4, Stefano Grisanti3,4, Federico Massa3,4, Matteo Bauckneht4,5, Alberto Miceli4,5, Michele Terzaghi6,7, Silvia Morbelli4,5, Flavio Nobili3,4, Dario Arnaldi3,4. 1. Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Largo P. Daneo, 3, 16132, Genoa, Italy. mattioli.pietro092@gmail.com. 2. IRCCS San Martino policlinical Hospital, Genoa, Italy. mattioli.pietro092@gmail.com. 3. Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Largo P. Daneo, 3, 16132, Genoa, Italy. 4. IRCCS San Martino policlinical Hospital, Genoa, Italy. 5. Nuclear Medicine, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. 6. Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy. 7. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Abstract
PURPOSE: To investigate brain functional correlates of mild cognitive impairment (MCI) in idiopathic REM sleep behavior disorder (iRBD). METHODS: Thirty-nine consecutive iRBD patients, 17 with (RBD-MCI, 73.6±6.5 years), and 22 without (RBD-NC, 69.6±6.1 years) MCI underwent neuropsychological assessment, 18F-FDG-PET, and 123I-FP-CIT-SPECT as a marker of nigro-striatal dopaminergic function. Forty-two healthy subjects (69.6±8.5 years) were used as control for 18F-FDG-PET analysis. Brain metabolism was compared between the three groups by univariate analysis of variance. Post hoc comparison between RBD-MCI and RBD-NC was performed to investigate the presence of an MCI-related volume of interest (MCI-VOI). Brain functional connectivity was explored by interregional correlation analysis (IRCA), using the whole-brain normalized MCI-VOI uptake as the independent variable. Moreover, the MCI-VOI uptake was correlated with 123I-FP-CIT-SPECT specific-to-non displaceable binding ratios (SBR) and neuropsychological variables. Finally, the MCI-VOI white matter structural connectivity was analyzed by using a MRI-derived human atlas. RESULTS: The MCI-VOI was characterized by a relative hypometabolism involving precuneus and cuneus (height threshold p<0.0001). IRCA (height threshold p<0.0001) revealed a brain functional network involving regions in frontal, temporal, parietal, and occipital lobes, thalamus, caudate, and red nuclei in iRBD patients. In controls, the network was smaller and involved temporal, occipital, cingulate cortex, and cerebellum. Moreover, MCI-VOI metabolism was correlated with verbal memory (p=0.01), executive functions (p=0.0001), and nigro-putaminal SBR (p=0.005). Finally, MCI-VOI was involved in a white matter network including cingulate fasciculus and corpus callosum. CONCLUSION: Our data suggest that cuneus/precuneus is a hub of a large functional network subserving cognitive function in iRBD.
PURPOSE: To investigate brain functional correlates of mild cognitive impairment (MCI) in idiopathic REM sleep behavior disorder (iRBD). METHODS: Thirty-nine consecutive iRBD patients, 17 with (RBD-MCI, 73.6±6.5 years), and 22 without (RBD-NC, 69.6±6.1 years) MCI underwent neuropsychological assessment, 18F-FDG-PET, and 123I-FP-CIT-SPECT as a marker of nigro-striatal dopaminergic function. Forty-two healthy subjects (69.6±8.5 years) were used as control for 18F-FDG-PET analysis. Brain metabolism was compared between the three groups by univariate analysis of variance. Post hoc comparison between RBD-MCI and RBD-NC was performed to investigate the presence of an MCI-related volume of interest (MCI-VOI). Brain functional connectivity was explored by interregional correlation analysis (IRCA), using the whole-brain normalized MCI-VOI uptake as the independent variable. Moreover, the MCI-VOI uptake was correlated with 123I-FP-CIT-SPECT specific-to-non displaceable binding ratios (SBR) and neuropsychological variables. Finally, the MCI-VOI white matter structural connectivity was analyzed by using a MRI-derived human atlas. RESULTS: The MCI-VOI was characterized by a relative hypometabolism involving precuneus and cuneus (height threshold p<0.0001). IRCA (height threshold p<0.0001) revealed a brain functional network involving regions in frontal, temporal, parietal, and occipital lobes, thalamus, caudate, and red nuclei in iRBD patients. In controls, the network was smaller and involved temporal, occipital, cingulate cortex, and cerebellum. Moreover, MCI-VOI metabolism was correlated with verbal memory (p=0.01), executive functions (p=0.0001), and nigro-putaminal SBR (p=0.005). Finally, MCI-VOI was involved in a white matter network including cingulate fasciculus and corpus callosum. CONCLUSION: Our data suggest that cuneus/precuneus is a hub of a large functional network subserving cognitive function in iRBD.
Authors: Jean-François Gagnon; Mélanie Vendette; Ronald B Postuma; Catherine Desjardins; Jessica Massicotte-Marquez; Michel Panisset; Jacques Montplaisir Journal: Ann Neurol Date: 2009-07 Impact factor: 10.422
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Authors: Ronald B Postuma; Alex Iranzo; Michele Hu; Birgit Högl; Bradley F Boeve; Raffaele Manni; Wolfgang H Oertel; Isabelle Arnulf; Luigi Ferini-Strambi; Monica Puligheddu; Elena Antelmi; Valerie Cochen De Cock; Dario Arnaldi; Brit Mollenhauer; Aleksandar Videnovic; Karel Sonka; Ki-Young Jung; Dieter Kunz; Yves Dauvilliers; Federica Provini; Simon J Lewis; Jitka Buskova; Milena Pavlova; Anna Heidbreder; Jacques Y Montplaisir; Joan Santamaria; Thomas R Barber; Ambra Stefani; Erik K St Louis; Michele Terzaghi; Annette Janzen; Smandra Leu-Semenescu; Guiseppe Plazzi; Flavio Nobili; Friederike Sixel-Doering; Petr Dusek; Frederik Bes; Pietro Cortelli; Kaylena Ehgoetz Martens; Jean-Francois Gagnon; Carles Gaig; Marco Zucconi; Claudia Trenkwalder; Ziv Gan-Or; Christine Lo; Michal Rolinski; Philip Mahlknecht; Evi Holzknecht; Angel R Boeve; Luke N Teigen; Gianpaolo Toscano; Geert Mayer; Silvia Morbelli; Benjamin Dawson; Amelie Pelletier Journal: Brain Date: 2019-03-01 Impact factor: 13.501