Hugh C Hendrie1,2,3, Valerie Smith-Gamble4, Kathleen A Lane5, Christianna Purnell1, Daniel O Clark1,2, Sujuan Gao4. 1. Indiana University Center for Aging Research, Indianapolis. 2. Regenstrief Institute, Inc., Indianapolis, Indiana. 3. Department of Psychiatry, Indiana University School of Medicine, Indianapolis. 4. Alvin C. York VA Medical Center, Murfreesboro, Tennessee. 5. Department of Biostatistics, Indiana University School of Medicine, Indianapolis.
Abstract
Objectives: To explore the possible association of childhood residence, education levels, and occupation with declining incidence rates of dementia in 2 cohorts of elderly African Americans. Methods: African Americans residing in Indianapolis without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years. The cohorts consist of 1,440 participants in 1992 and 1,835 participants in 2001 aged 70 years and older. Cox proportional hazard regression models were used to compare cohort differences in dementia and Alzheimer's disease (AD) risk. Results: The 2001 cohort had significantly decreased risk of both incident dementia and AD (hazard ratio [HR]: 0.62/0.57 for dementia/AD). Years of education was associated with decreased risk of dementia (HR = 0.93; p = .0011). A significant interaction (p = .0477) between education and childhood rural residence was found for the risk of AD that higher education level is significantly associated with reduced AD risk (HR = 0.87) in participants with childhood rural residence, but no association in those with urban upbringing. The cohort difference for dementia rates were attenuated by adjusting for the 3 risk factors but remained significant (HR = 0.75; p = .04). Discussion: These results emphasize the importance of early life factors including rural residence and education for the risk for dementia later in life.
Objectives: To explore the possible association of childhood residence, education levels, and occupation with declining incidence rates of dementia in 2 cohorts of elderly African Americans. Methods: African Americans residing in Indianapolis without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years. The cohorts consist of 1,440 participants in 1992 and 1,835 participants in 2001 aged 70 years and older. Cox proportional hazard regression models were used to compare cohort differences in dementia and Alzheimer's disease (AD) risk. Results: The 2001 cohort had significantly decreased risk of both incident dementia and AD (hazard ratio [HR]: 0.62/0.57 for dementia/AD). Years of education was associated with decreased risk of dementia (HR = 0.93; p = .0011). A significant interaction (p = .0477) between education and childhood rural residence was found for the risk of AD that higher education level is significantly associated with reduced AD risk (HR = 0.87) in participants with childhood rural residence, but no association in those with urban upbringing. The cohort difference for dementia rates were attenuated by adjusting for the 3 risk factors but remained significant (HR = 0.75; p = .04). Discussion: These results emphasize the importance of early life factors including rural residence and education for the risk for dementia later in life.
Authors: Jennifer J Manly; Diane M Jacobs; Pegah Touradji; Scott A Small; Yaakov Stern Journal: J Int Neuropsychol Soc Date: 2002-03 Impact factor: 2.892
Authors: H C Hendrie; A Ogunniyi; K S Hall; O Baiyewu; F W Unverzagt; O Gureje; S Gao; R M Evans; A O Ogunseyinde; A O Adeyinka; B Musick; S L Hui Journal: JAMA Date: 2001-02-14 Impact factor: 56.272
Authors: Sujuan Gao; Adesola Ogunniyi; Kathleen S Hall; Olusegun Baiyewu; Frederick W Unverzagt; Kathleen A Lane; Jill R Murrell; Oye Gureje; Ann M Hake; Hugh C Hendrie Journal: Alzheimers Dement Date: 2015-07-26 Impact factor: 21.566
Authors: J C Morris; A Heyman; R C Mohs; J P Hughes; G van Belle; G Fillenbaum; E D Mellits; C Clark Journal: Neurology Date: 1989-09 Impact factor: 9.910
Authors: Sujuan Gao; Heather N Burney; Chris M Callahan; Christianna E Purnell; Hugh C Hendrie Journal: J Am Geriatr Soc Date: 2019-06-20 Impact factor: 5.562
Authors: Katrina M Walsemann; Stephanie Ureña; Mateo P Farina; Jennifer A Ailshire Journal: J Gerontol B Psychol Sci Soc Sci Date: 2022-08-11 Impact factor: 4.942
Authors: Dahyun Yi; Younghwa Lee; Min Soo Byun; Jun Ho Lee; Kang Ko; Bo Kyung Sohn; Young Min Choe; Hyo Jung Choi; Hyewon Baek; Chul-Ho Sohn; Yu Kyeong Kim; Dong Young Lee Journal: Alzheimers Res Ther Date: 2018-08-23 Impact factor: 6.982
Authors: Anna Papazoglou; Muhammad I Arshaad; Christina Henseler; Johanna Daubner; Karl Broich; Britta Haenisch; Marco Weiergräber Journal: Curr Alzheimer Res Date: 2021 Impact factor: 3.498