Sujuan Gao1, Adesola Ogunniyi2, Kathleen S Hall3, Olusegun Baiyewu4, Frederick W Unverzagt3, Kathleen A Lane5, Jill R Murrell6, Oye Gureje4, Ann M Hake7, Hugh C Hendrie8. 1. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: sgao@iu.edu. 2. Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria. 3. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. 4. Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria. 5. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA. 6. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. 7. Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA. 8. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA.
Abstract
INTRODUCTION: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and 2001. METHODS: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. RESULTS: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%-4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%-1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. DISCUSSION: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.
INTRODUCTION: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and 2001. METHODS: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. RESULTS: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%-4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%-1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. DISCUSSION: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.
Authors: M X Tang; P Cross; H Andrews; D M Jacobs; S Small; K Bell; C Merchant; R Lantigua; R Costa; Y Stern; R Mayeux Journal: Neurology Date: 2001-01-09 Impact factor: 9.910
Authors: E M C Schrijvers; B F J Verhaaren; P J Koudstaal; A Hofman; M A Ikram; M M B Breteler Journal: Neurology Date: 2012-05-02 Impact factor: 9.910
Authors: H C Hendrie; A Ogunniyi; K S Hall; O Baiyewu; F W Unverzagt; O Gureje; S Gao; R M Evans; A O Ogunseyinde; A O Adeyinka; B Musick; S L Hui Journal: JAMA Date: 2001-02-14 Impact factor: 56.272
Authors: Annette L Fitzpatrick; Lewis H Kuller; Diane G Ives; Oscar L Lopez; William Jagust; John C S Breitner; Beverly Jones; Constantine Lyketsos; Corinne Dulberg Journal: J Am Geriatr Soc Date: 2004-02 Impact factor: 5.562
Authors: Fiona E Matthews; Antony Arthur; Linda E Barnes; John Bond; Carol Jagger; Louise Robinson; Carol Brayne Journal: Lancet Date: 2013-07-17 Impact factor: 79.321
Authors: Sujuan Gao; Heather N Burney; Chris M Callahan; Christianna E Purnell; Hugh C Hendrie Journal: J Am Geriatr Soc Date: 2019-06-20 Impact factor: 5.562
Authors: Andrea Denny; Marissa Streitz; Kristin Stock; Joyce E Balls-Berry; Lisa L Barnes; Goldie S Byrd; Raina Croff; Sujuan Gao; Crystal M Glover; Hugh C Hendrie; William T Hu; Jennifer J Manly; Krista L Moulder; Susan Stark; Stephen B Thomas; Rachel Whitmer; Roger Wong; John C Morris; Jennifer H Lingler Journal: Alzheimers Dement Date: 2020-08-17 Impact factor: 21.566
Authors: Jennifer Weuve; Kumar B Rajan; Lisa L Barnes; Robert S Wilson; Denis A Evans Journal: J Gerontol B Psychol Sci Soc Sci Date: 2018-04-16 Impact factor: 4.077