Davide Bruno1, Rebecca L Koscik2, John L Woodard3, Nunzio Pomara4, Sterling C Johnson5. 1. School of Natural Science and Psychology,Liverpool John Moores University,Liverpool,UK;Department of Psychology,Liverpool Hope University,Liverpool,UK. 2. Wisconsin Alzheimer's Institute,School of Medicine and Public Health,University of Wisconsin-Madison,Madison,WI,USA. 3. Department of Psychology,Wayne State University,Detroit,Michigan,USA. 4. Nathan Kline Institute for Psychiatric Research,Orangeburg,New York,USA;Department of Psychiatry,School of Medicine,New York University,New York City,New York,USA. 5. Geriatric Research Education and Clinical Center,Wm. S. Middleton Veterans Hospital,Madison,Wisconsin,USA.
Abstract
ABSTRACT Objectives: Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (Journal of Clinical and Experimental Neuropsychology, Vol. 38, 2016, pp. 967-973) have shown that higher ratio scores between immediate and delayed recency (i.e. the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline. DESIGN: Data were analyzed longitudinally with binomial regression. Baseline scores were used to predict conversion to early MCI after approximately nine years. SETTING: Data were collected at the Wisconsin Registry of Alzheimer's Prevention, in Madison, Wisconsin. PARTICIPANTS: For the study, 427 individuals were included in the analysis; all participants were 50 years of age or older and cognitively intact at baseline, and were native English speakers. MEASUREMENTS: Memory data were collected using the Rey's Auditory Verbal Learning Test, and the early MCI diagnosis was obtained via consensus conference. RESULTS: Our results showed that higher Rr scores are correlated with greater risk of later early MCI diagnosis, and this association is independent of total recall performance. CONCLUSIONS: Rr is an emerging cognitive marker of cognitive decline.
ABSTRACT Objectives: Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (Journal of Clinical and Experimental Neuropsychology, Vol. 38, 2016, pp. 967-973) have shown that higher ratio scores between immediate and delayed recency (i.e. the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline. DESIGN: Data were analyzed longitudinally with binomial regression. Baseline scores were used to predict conversion to early MCI after approximately nine years. SETTING: Data were collected at the Wisconsin Registry of Alzheimer's Prevention, in Madison, Wisconsin. PARTICIPANTS: For the study, 427 individuals were included in the analysis; all participants were 50 years of age or older and cognitively intact at baseline, and were native English speakers. MEASUREMENTS: Memory data were collected using the Rey's Auditory Verbal Learning Test, and the early MCI diagnosis was obtained via consensus conference. RESULTS: Our results showed that higher Rr scores are correlated with greater risk of later early MCI diagnosis, and this association is independent of total recall performance. CONCLUSIONS: Rr is an emerging cognitive marker of cognitive decline.
Entities:
Keywords:
Alzheimer's disease; early MCI; recency ratio; serial position
Authors: Rebecca L Koscik; Sara E Berman; Lindsay R Clark; Kimberly D Mueller; Ozioma C Okonkwo; Carey E Gleason; Bruce P Hermann; Mark A Sager; Sterling C Johnson Journal: J Int Neuropsychol Soc Date: 2016-11 Impact factor: 2.892
Authors: Davide Bruno; Jay Nierenberg; Thomas B Cooper; Charles R Marmar; Henrik Zetterberg; Kaj Blennow; Kenji Hashimoto; Nunzio Pomara Journal: Neurobiol Learn Mem Date: 2017-03-18 Impact factor: 2.877
Authors: Rebecca L Koscik; Asenath La Rue; Erin M Jonaitis; Ozioma C Okonkwo; Sterling C Johnson; Barbara B Bendlin; Bruce P Hermann; Mark A Sager Journal: Dement Geriatr Cogn Disord Date: 2014-02-20 Impact factor: 2.959
Authors: Lindsay R Clark; Rebecca L Koscik; Christopher R Nicholas; Ozioma C Okonkwo; Corinne D Engelman; Lisa C Bratzke; Kirk J Hogan; Kimberly D Mueller; Barbara B Bendlin; Cynthia M Carlsson; Sanjay Asthana; Mark A Sager; Bruce P Hermann; Sterling C Johnson Journal: Arch Clin Neuropsychol Date: 2016-11-22 Impact factor: 2.813
Authors: Corinne D Engelman; Rebecca L Koscik; Erin M Jonaitis; Ozioma C Okonkwo; Bruce P Hermann; Asenath La Rue; Mark A Sager Journal: J Alzheimers Dis Date: 2013 Impact factor: 4.472
Authors: Davide Bruno; Carey E Gleason; Rebecca L Koscik; Nunzio Pomara; Henrik Zetterberg; Kaj Blennow; Sterling C Johnson Journal: Int J Geriatr Psychiatry Date: 2018-12-10 Impact factor: 3.485
Authors: Davide Bruno; Chelsea Reichert Plaska; Daniel P A Clark; Henrik Zetterberg; Kaj Blennow; Marcel M Verbeek; Nunzio Pomara Journal: Int J Neurosci Date: 2020-03-31 Impact factor: 2.292