Davide Bruno1, Kimberly D Mueller2,3,4, Tobey Betthauser4,5, Nathaniel Chin4,5, Corinne D Engelman3,4,6, Bradley Christian4,7,8, Rebecca L Koscik3,5, Sterling C Johnson3,4,9. 1. School of Psychology, Liverpool John Moores University, Liverpool, UK. 2. Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, USA. 3. Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. 4. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, USA, Madison, WI, USA. 5. Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. 6. Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA. 7. Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA. 8. Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA. 9. Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, USA, Madison, WI, USA.
Abstract
BACKGROUND: Story recall is a frequently used neuropsychological test of episodic memory with clinical populations and for screening participants in drug trials for Alzheimer's disease. However, it is unclear at this stage which underlying mechanisms confer the test its sensitivity. In this paper, we examined serial position effects, that is, better recall for items learned early and late on a list, in story recall, and their usefulness to predict early changes associated with neurodegenerative markers. METHODS: We analysed data from the Wisconsin Registry for Alzheimer's Prevention. First, we tested whether serial position effects were present in story recall (measured with the Wechsler Memory Scale Logical Memory Task; LMT) across individuals who were classified as cognitively unimpaired - stable, cognitively unimpaired - declining, or as having mild cognitive impairment (MCI). RESULTS: Our results showed clear serial position effects for all groups, except for delayed recall among individuals with MCI, where no primacy effect was observed. Second, we tested whether loss of primacy from immediate to delayed recall was associated with amyloid burden (as measured with PiB PET) in individuals who were cognitively unimpaired at baseline. We found that more primacy loss predicted amyloid positivity, above and beyond the LMT total score. CONCLUSIONS: This report is the first to show that loss of primacy between immediate and delayed story recall is associated with amyloid burden.
BACKGROUND: Story recall is a frequently used neuropsychological test of episodic memory with clinical populations and for screening participants in drug trials for Alzheimer's disease. However, it is unclear at this stage which underlying mechanisms confer the test its sensitivity. In this paper, we examined serial position effects, that is, better recall for items learned early and late on a list, in story recall, and their usefulness to predict early changes associated with neurodegenerative markers. METHODS: We analysed data from the Wisconsin Registry for Alzheimer's Prevention. First, we tested whether serial position effects were present in story recall (measured with the Wechsler Memory Scale Logical Memory Task; LMT) across individuals who were classified as cognitively unimpaired - stable, cognitively unimpaired - declining, or as having mild cognitive impairment (MCI). RESULTS: Our results showed clear serial position effects for all groups, except for delayed recall among individuals with MCI, where no primacy effect was observed. Second, we tested whether loss of primacy from immediate to delayed recall was associated with amyloid burden (as measured with PiB PET) in individuals who were cognitively unimpaired at baseline. We found that more primacy loss predicted amyloid positivity, above and beyond the LMT total score. CONCLUSIONS: This report is the first to show that loss of primacy between immediate and delayed story recall is associated with amyloid burden.
Authors: Rebecca L Koscik; Sara E Berman; Lindsay R Clark; Kimberly D Mueller; Ozioma C Okonkwo; Carey E Gleason; Bruce P Hermann; Mark A Sager; Sterling C Johnson Journal: J Int Neuropsychol Soc Date: 2016-11 Impact factor: 2.892
Authors: Chiara Stella Turchetta; Roberta Perri; Lucia Fadda; Giulia Caruso; Maria Stefania De Simone; Carlo Caltagirone; Giovanni Augusto Carlesimo Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Burcu F Darst; Rebecca L Koscik; Annie M Racine; Jennifer M Oh; Rachel A Krause; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Bradley T Christian; Barbara B Bendlin; Ozioma C Okonkwo; Kirk J Hogan; Bruce P Hermann; Mark A Sager; Sanjay Asthana; Sterling C Johnson; Corinne D Engelman Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Eliane Correa Miotto; Sonia Maria Dozzi Brucki; Carlos T Cerqueira; Paulo R Bazán; Geise Aline de Almeida Silva; Maria da Graça M Martin; Paula Squarzoni da Silveira; Daniele de Paula Faria; Artur Martins Coutinho; Carlos Alberto Buchpiguel; Geraldo Busatto Filho; Ricardo Nitrini Journal: J Alzheimers Dis Date: 2022 Impact factor: 4.160