Stefan Herz1, Patrick Vogel2,3, Philipp Dietrich2, Thomas Kampf3,4, Martin A Rückert3, Ralph Kickuth2, Volker C Behr3, Thorsten A Bley2. 1. Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Oberdürrbacherstrasse 6, 97080, Würzburg, Germany. Herz_s@ukw.de. 2. Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Oberdürrbacherstrasse 6, 97080, Würzburg, Germany. 3. Department of Experimental Physics V, University of Würzburg, Würzburg, Germany. 4. Department of Diagnostic and Interventional Neuroradiology, University Hospital Würzburg, Würzburg, Germany.
Abstract
PURPOSE: To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model. MATERIALS AND METHODS: Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time. RESULTS: Visualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions. CONCLUSION: Real-time MPI-guided PTA in a phantom model is feasible.
PURPOSE: To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model. MATERIALS AND METHODS: Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time. RESULTS: Visualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions. CONCLUSION: Real-time MPI-guided PTA in a phantom model is feasible.
Authors: M Graeser; F Thieben; P Szwargulski; F Werner; N Gdaniec; M Boberg; F Griese; M Möddel; P Ludewig; D van de Ven; O M Weber; O Woywode; B Gleich; T Knopp Journal: Nat Commun Date: 2019-04-26 Impact factor: 14.919
Authors: Patrick Vogel; Jonathan Markert; Martin A Rückert; Stefan Herz; Benedikt Keßler; Kilian Dremel; Daniel Althoff; Matthias Weber; Thorsten M Buzug; Thorsten A Bley; Walter H Kullmann; Randolf Hanke; Simon Zabler; Volker C Behr Journal: Sci Rep Date: 2019-09-02 Impact factor: 4.996
Authors: Franz Wegner; Thorsten M Buzug; Anna C Bakenecker; Anselm von Gladiss; Hannes Schwenke; André Behrends; Thomas Friedrich; Kerstin Lüdtke-Buzug; Alexander Neumann; Joerg Barkhausen Journal: Sci Rep Date: 2021-07-07 Impact factor: 4.379