| Literature DB >> 29661881 |
M Angeles Argudín1, S Roisin2, L Nienhaus2, M Dodémont2, R de Mendonça2, C Nonhoff2, A Deplano2, O Denis2,3.
Abstract
Methicillin-resistant Staphylococcus aureus isolates lacking mec genes (n = 32), collected from Belgian hospitals, were characterized for their β-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpP and yjbH). Twelve isolates were β-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.Entities:
Keywords: BORSA; MODSA; PBP; β-lactamase
Mesh:
Substances:
Year: 2018 PMID: 29661881 PMCID: PMC6021684 DOI: 10.1128/AAC.00091-18
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191