Literature DB >> 29661881

Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes.

M Angeles Argudín1, S Roisin2, L Nienhaus2, M Dodémont2, R de Mendonça2, C Nonhoff2, A Deplano2, O Denis2,3.   

Abstract

Methicillin-resistant Staphylococcus aureus isolates lacking mec genes (n = 32), collected from Belgian hospitals, were characterized for their β-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpP and yjbH). Twelve isolates were β-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  BORSA; MODSA; PBP; β-lactamase

Mesh:

Substances:

Year:  2018        PMID: 29661881      PMCID: PMC6021684          DOI: 10.1128/AAC.00091-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  29 in total

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Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

2.  Loss of function of the gdpP protein leads to joint β-lactam/glycopeptide tolerance in Staphylococcus aureus.

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3.  Association of borderline oxacillin-susceptible strains of Staphylococcus aureus with surgical wound infections.

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5.  Clonal spread of Staphylococcus aureus with reduced susceptibility to oxacillin in a dermatological hospital unit.

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6.  Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance.

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7.  Failure of cloxacillin in treatment of a patient with borderline oxacillin-resistant Staphylococcus aureus endocarditis.

Authors:  Stuart Skinner; Melanie Murray; Tom Walus; James A Karlowsky
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8.  Low occurrence of the new species Staphylococcus argenteus in a Staphylococcus aureus collection of human isolates from Belgium.

Authors:  M A Argudín; M Dodémont; S Vandendriessche; S Rottiers; C Tribes; S Roisin; R de Mendonça; C Nonhoff; A Deplano; O Denis
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-04-04       Impact factor: 3.267

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5.  c-di-AMP Accumulation Impairs Muropeptide Synthesis in Listeria monocytogenes.

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6.  Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus.

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8.  Borderline resistance to oxacillin in Staphylococcus aureus after treatment with sub-lethal sodium hypochlorite concentrations.

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9.  In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus.

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10.  Prevalence and antibiogram of coagulase negative Staphylococci in bioaerosols from different indoors of a university in India.

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