Literature DB >> 21986827

Loss of function of the gdpP protein leads to joint β-lactam/glycopeptide tolerance in Staphylococcus aureus.

J M Griffiths1, A J O'Neill.   

Abstract

The genetic basis of tolerance to inhibitors of peptidoglycan biosynthesis in Staphylococcus aureus was investigated by generating tolerant mutants in vitro and characterizing them by comparative genome sequencing. Two independently selected tolerant mutants harbored nonsynonymous mutations in gdpP, a gene encoding a putative membrane-located signaling protein. Insertional inactivation of gdpP also conferred tolerance. Our findings further implicate altered signal transduction as a route to antibiotic tolerance in S. aureus.

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Year:  2011        PMID： 21986827      PMCID： PMC3256080          DOI： 10.1128/AAC.05148-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Journal:  Rev Infect Dis       Date:  1985 May-Jun

2.  Effect of storage and changes in bacterial growth phase and antibiotic concentrations on antimicrobial tolerance in Staphylococcus aureus.

Authors:  C G Mayhall; E Apollo
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

3.  Glycopeptide tolerance in Staphylococcus aureus.

Authors:  J May; K Shannon; A King; G French
Journal:  J Antimicrob Chemother       Date:  1998-08       Impact factor: 5.790

4.  Acid- and multistress-resistant mutants of Lactococcus lactis : identification of intracellular stress signals.

Authors:  F Rallu; A Gruss; S D Ehrlich; E Maguin
Journal:  Mol Microbiol       Date:  2000-02       Impact factor: 3.501

5.  In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance.

Authors:  Katy L Blake; Chris P Randall; Alex J O'Neill
Journal:  Antimicrob Agents Chemother       Date:  2011-02-07       Impact factor: 5.191

6.  Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.

Authors:  Tadashi Baba; Taeok Bae; Olaf Schneewind; Fumihiko Takeuchi; Keiichi Hiramatsu
Journal:  J Bacteriol       Date:  2007-10-19       Impact factor: 3.490

7.  A vector for systematic gene inactivation in Bacillus subtilis.

Authors:  Valerie Vagner; Etienne Dervyn; S Dusko Ehrlich
Journal:  Microbiology (Reading)       Date:  1998-11       Impact factor: 2.777

8.  A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP.

Authors:  Linda M Holland; Sinéad T O'Donnell; Dmitri A Ryjenkov; Larissa Gomelsky; Shawn R Slater; Paul D Fey; Mark Gomelsky; James P O'Gara
Journal:  J Bacteriol       Date:  2008-05-23       Impact factor: 3.490

9.  sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.

Authors:  Malcolm J Horsburgh; Joanne L Aish; Ian J White; Les Shaw; James K Lithgow; Simon J Foster
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

Review 10.  Molecular control of bacterial death and lysis.

Authors:  Kelly C Rice; Kenneth W Bayles
Journal:  Microbiol Mol Biol Rev       Date:  2008-03       Impact factor: 11.056
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  49 in total

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Journal:  Biochemistry       Date:  2016-02-03       Impact factor: 3.162

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Authors:  Meiping Ye; Jun-Jie Zhang; Xin Fang; Gavin B Lawlis; Bryan Troxell; Yan Zhou; Mark Gomelsky; Yongliang Lou; X Frank Yang
Journal:  Infect Immun       Date:  2014-02-24       Impact factor: 3.441

4.  c-di-AMP-Regulated K+ Importer KtrAB Affects Biofilm Formation, Stress Response, and SpeB Expression in Streptococcus pyogenes.

Authors:  Sabrina Faozia; Tazin Fahmi; Gary C Port; Kyu Hong Cho
Journal:  Infect Immun       Date:  2021-03-17       Impact factor: 3.441

Review 5.  Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria.

Authors:  Fabian M Commichau; Jana L Heidemann; Ralf Ficner; Jörg Stülke
Journal:  J Bacteriol       Date:  2018-12-07       Impact factor: 3.490

6.  Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response.

Authors:  Casey M Gries; Eric L Bruger; Derek E Moormeier; Tyler D Scherr; Christopher M Waters; Tammy Kielian
Journal:  Infect Immun       Date:  2016-11-18       Impact factor: 3.441

7.  Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence.

Authors:  Yinlan Bai; Jun Yang; Leslie E Eisele; Adam J Underwood; Benjamin J Koestler; Christopher M Waters; Dennis W Metzger; Guangchun Bai
Journal:  J Bacteriol       Date:  2013-09-06       Impact factor: 3.490

8.  A Novel Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci.

Authors:  Xu Wang; Milya Davlieva; Jinnethe Reyes; Diana Panesso; Cesar A Arias; Yousif Shamoo
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

9.  Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein.

Authors:  Adam J Underwood; Yang Zhang; Dennis W Metzger; Guangchun Bai
Journal:  J Microbiol Methods       Date:  2014-09-16       Impact factor: 2.363

10.  Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection.

Authors:  Jun Yang; Yinlan Bai; Yang Zhang; Vincent D Gabrielle; Lei Jin; Guangchun Bai
Journal:  Mol Microbiol       Date:  2014-05-23       Impact factor: 3.501
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