Literature DB >> 2961719

Vascular and neural changes in the rat optic nerve following induction of diabetes with streptozotocin.

T M Scott1, J Foote, B Peat, G Galway.   

Abstract

This study was undertaken to determine whether or not changes occur in blood vessels, axons or glia of the optic nerve as the result of streptozotocin-induced diabetes. Diabetes was induced in 4 weeks old Sprague-Dawley rats. At 12 and 16 weeks of age, the rats were killed and the optic nerves prepared for examination. The number and density of blood vessels was found to be significantly increased in the diabetic rats. No alteration in the structure of the blood vessels was noted. A decrease in the percentage volume of axons and an increase in the percentage volume of glial elements accompanied the increase in blood vessels in the diabetic rats. No difference was found in the spectrum of fibre diameters.

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Year:  1986        PMID： 2961719      PMCID： PMC1166470     

Source DB:  PubMed          Journal:  J Anat        ISSN： 0021-8782            Impact factor:   2.610


  13 in total

1.  SCHWANN-CELL ABNORMALITIES IN DIABETIC NEUROPATHY.

Authors:  P K THOMAS; R G LASCELLES
Journal:  Lancet       Date:  1965-06-26       Impact factor: 79.321

2.  PAPILLEDEMA AND PAPILLITIS IN DIABETES: REPORT OF TWO CASES.

Authors:  M FREUND; A CARMON; A M COHEN
Journal:  Am J Ophthalmol       Date:  1965-07       Impact factor: 5.258

3.  Optic nerve involvement in diabetes.

Authors:  L Yanko; U Ticho; M Ivry
Journal:  Acta Ophthalmol (Copenh)       Date:  1972

Review 4.  Deterioration of the microcirculation in diabetes.

Authors:  D E McMillan
Journal:  Diabetes       Date:  1975-10       Impact factor: 9.461

5.  Ischemic optic neuropathy.

Authors:  G R Miller; J L Smith
Journal:  Am J Ophthalmol       Date:  1966-07       Impact factor: 5.258

6.  Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.

Authors:  M A Stewart; W R Sherman; M M Kurien; G I Moonsammy; M Wisgerhof
Journal:  J Neurochem       Date:  1967-11       Impact factor: 5.372

Review 7.  Diabetic retinopathy.

Authors:  F A L'Esperance
Journal:  Med Clin North Am       Date:  1978-07       Impact factor: 5.456

8.  Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.

Authors:  K H Gabbay; L O Merola; R A Field
Journal:  Science       Date:  1966-01-14       Impact factor: 47.728

9.  The postnatal development of blood vessels in the optic nerve of normotensive and hypertensive rats.

Authors:  T M Scott; J Foote
Journal:  J Anat       Date:  1984-06       Impact factor: 2.610

10.  The natural history of diabetic retinopathy.

Authors:  E M Kohner
Journal:  J R Coll Physicians Lond       Date:  1972-04
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  14 in total

Review 1.  Diabetic retinopathy is a neurodegenerative disorder.

Authors:  Stephanie K Lynch; Michael D Abràmoff
Journal:  Vision Res       Date:  2017-04-28       Impact factor: 1.886

2.  Diabetic Retinopathy and the NMDA Receptor.

Authors:  Sylvia B. Smith
Journal:  Drug News Perspect       Date:  2002-05

Review 3.  Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy.

Authors:  S Priya Narayanan; Esraa Shosha; Chithra D Palani
Journal:  Pharmacol Res       Date:  2019-06-15       Impact factor: 7.658

Review 4.  The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy.

Authors:  Alistair J Barber; Thomas W Gardner; Steven F Abcouwer
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-02-28       Impact factor: 4.799

5.  Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.

Authors:  Yanling Liu; Lan Franco Leo; Corban McGregor; Anzor Grivitishvili; Colin J Barnstable; Joyce Tombran-Tink
Journal:  Mol Med       Date:  2012-12-20       Impact factor: 6.354

6.  In diabetic eyes, multifocal ERG reflects differences in function between the nasal part and the temporal part of the macula.

Authors:  Kristina Holm; Monica Lövestam Adrian
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2012-02-14       Impact factor: 3.117

7.  Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

Authors:  A J Barber; E Lieth; S A Khin; D A Antonetti; A G Buchanan; T W Gardner
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

Review 8.  Retinal ganglion cells in diabetes.

Authors:  Timothy S Kern; Alistair J Barber
Journal:  J Physiol       Date:  2008-06-19       Impact factor: 5.182

9.  Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy.

Authors:  Birthe Meyer-Rüsenberg; Mitrofanis Pavlidis; Tobias Stupp; Solon Thanos
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2006-12-21       Impact factor: 3.535

10.  Decrease in retinal neuronal cells in streptozotocin-induced diabetic mice.

Authors:  Yang Yang; Danna Mao; Xinke Chen; Ling Zhao; Qing Tian; Chenggang Liu; Bo Lei Shanbi Zhou
Journal:  Mol Vis       Date:  2012-06-01       Impact factor: 2.367
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