Literature DB >> 5907911

Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.

K H Gabbay, L O Merola, R A Field.   

Abstract

Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.

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Year:  1966        PMID： 5907911     DOI： 10.1126/science.151.3707.209

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  74 in total

1.  Functional expression of novel human and murine AKR1B genes.

Authors:  Joshua K Salabei; Xiao-Ping Li; J Mark Petrash; Aruni Bhatnagar; Oleg A Barski
Journal:  Chem Biol Interact       Date:  2011-01-27       Impact factor: 5.192

2.  [The role of AGEs and ROS in atherosclerosis].

Authors:  Alin Stirban
Journal:  Herz       Date:  2010-05       Impact factor: 1.443

3.  Metabolism of the aldose reductase inhibitor ALO1567 in man.

Authors:  Y H Park; J E Hudson; R C Barker; B M York; R K Brazzell
Journal:  Br J Clin Pharmacol       Date:  1991-08       Impact factor: 4.335

Review 4.  The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.

Authors:  Oleg A Barski; Srinivas M Tipparaju; Aruni Bhatnagar
Journal:  Drug Metab Rev       Date:  2008       Impact factor: 4.518

5.  Dose-dependent pharmacokinetics of the aldose reductase inhibitor imirestat in man.

Authors:  R K Brazzell; P R Mayer; R Dobbs; P J McNamara; R L Teng; J T Slattery
Journal:  Pharm Res       Date:  1991-01       Impact factor: 4.200

Review 6.  Aldose reductase inhibitors in the treatment of diabetic neuropathy. A review of the rationale and clinical evidence.

Authors:  E A Masson; A J Boulton
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

Review 7.  Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia.

Authors:  Sergiu-Bogdan Catrina
Journal:  J Mol Med (Berl)       Date:  2014-06-12       Impact factor: 4.599

Review 8.  Vascular factors in diabetic neuropathy.

Authors:  S Tesfaye; R Malik; J D Ward
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

9.  Metabolic alterations in the human erythrocyte produced by increases in glucose concentration. The role of the polyol pathway.

Authors:  S F Travis; A D Morrison; R S Clements; A I Winegrad; F A Oski
Journal:  J Clin Invest       Date:  1971-10       Impact factor: 14.808

10.  Influence of dietary myoinositol on nerve conduction and inositol phospholipids in normal and diabetic rats.

Authors:  J G Jefferys; K P Palmano; A K Sharma; P K Thomas
Journal:  J Neurol Neurosurg Psychiatry       Date:  1978-04       Impact factor: 10.154
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