Eun-Joo Park1,2, Yun Deok Ahn2, Jae Young Lee3,4. 1. Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. 2. Department of Radiology, Seoul National University Hospital, Korea, Seoul, Korea. 3. Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. leejy4u@snu.ac.kr. 4. Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea. leejy4u@snu.ac.kr.
Abstract
OBJECTIVES: This study was designed to investigate whether focused ultrasound (FUS) treatment with a higher mechanical index (MI) can enhance the effects of combined chemotherapy more than with a lower MI, and to evaluate the feasibility of the chemotherapy combined with FUS at a higher MI as an alternative treatment protocol. METHODS: Mice in the first study were divided into six groups: control, chemotherapy only (GEM), two groups treated with FUS only at two different MIs, and two groups treated with chemotherapy and FUS (GEM + FUS). Mice were treated with a single-session treatment; one session consisted of three weekly treatments and 1 week of follow-up monitoring. In the second study, mice were assigned to two groups (GEM, GEM + FUS) and treated with four treatment sessions. RESULTS: In the single-session treatment, tumor growth was most effectively suppressed in GEM + FUS group with a higher MI. Tumor growth rate was significantly lower in GEM + FUS group than in GEM group for multiple-session treatment. Specifically, three of ten mice in GEM + FUS group showed complete remission. CONCLUSIONS: This study demonstrated that FUS at a higher MI can enhance chemotherapy outcomes more than at a lower MI and demonstrated the potential of FUS in combination with chemotherapy as a new cancer treatment protocol. KEY POINTS: • Combined treatment of chemotherapy and focused ultrasound can effectively suppress tumor growth. • For the focused ultrasound treatment conditions used in this study, focused ultrasound with relatively higher mechanical index shows more enhanced therapeutic outcomes than with the lower mechanical index. • Combination therapy shows the possibility as a new cancer treatment protocol.
OBJECTIVES: This study was designed to investigate whether focused ultrasound (FUS) treatment with a higher mechanical index (MI) can enhance the effects of combined chemotherapy more than with a lower MI, and to evaluate the feasibility of the chemotherapy combined with FUS at a higher MI as an alternative treatment protocol. METHODS:Mice in the first study were divided into six groups: control, chemotherapy only (GEM), two groups treated with FUS only at two different MIs, and two groups treated with chemotherapy and FUS (GEM + FUS). Mice were treated with a single-session treatment; one session consisted of three weekly treatments and 1 week of follow-up monitoring. In the second study, mice were assigned to two groups (GEM, GEM + FUS) and treated with four treatment sessions. RESULTS: In the single-session treatment, tumor growth was most effectively suppressed in GEM + FUS group with a higher MI. Tumor growth rate was significantly lower in GEM + FUS group than in GEM group for multiple-session treatment. Specifically, three of ten mice in GEM + FUS group showed complete remission. CONCLUSIONS: This study demonstrated that FUS at a higher MI can enhance chemotherapy outcomes more than at a lower MI and demonstrated the potential of FUS in combination with chemotherapy as a new cancer treatment protocol. KEY POINTS: • Combined treatment of chemotherapy and focused ultrasound can effectively suppress tumor growth. • For the focused ultrasound treatment conditions used in this study, focused ultrasound with relatively higher mechanical index shows more enhanced therapeutic outcomes than with the lower mechanical index. • Combination therapy shows the possibility as a new cancer treatment protocol.
Entities:
Keywords:
Chemotherapy; Focused ultrasound; Image guided; Mechanical index; Pancreatic cancer
Authors: Douglas L Miller; Nadine B Smith; Michael R Bailey; Gregory J Czarnota; Kullervo Hynynen; Inder Raj S Makin Journal: J Ultrasound Med Date: 2012-04 Impact factor: 2.153
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