Literature DB >> 29581110

Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China.

Xin Hou1,2,3, Meng Xiao1,3, He Wang1,3, Shu-Ying Yu1,2,3, Ge Zhang1,3, Yanan Zhao4, Ying-Chun Xu5,2,3.   

Abstract

Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Candida glabrata sensu stricto; MSH2; PDR1; antifungal resistance

Mesh：

Substances：

Year:  2018        PMID： 29581110      PMCID： PMC5971605          DOI： 10.1128/AAC.00153-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  31 in total

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Review 2.  Invasive Candidiasis.

Authors:  Bart Jan Kullberg; Maiken C Arendrup
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3.  Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata.

Authors:  M A Pfaller; M Castanheira; S R Lockhart; A M Ahlquist; S A Messer; R N Jones
Journal:  J Clin Microbiol       Date:  2012-01-25       Impact factor: 5.948

Review 4.  Azole Resistance in Candida glabrata.

Authors:  Sarah G Whaley; P David Rogers
Journal:  Curr Infect Dis Rep       Date:  2016-12       Impact factor: 3.725

5.  Multilocus sequence type analysis reveals both clonality and recombination in populations of Candida glabrata bloodstream isolates from U.S. surveillance studies.

Authors:  Timothy J Lott; João P Frade; Shawn R Lockhart
Journal:  Eukaryot Cell       Date:  2010-02-26

Review 6.  Candida glabrata--unique features and challenges in the clinical management of invasive infections.

Authors:  A Glöckner; O A Cornely
Journal:  Mycoses       Date:  2015-08       Impact factor: 4.377

7.  Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria.

Authors:  Ulrike Klotz; Dirk Schmidt; Birgit Willinger; Eike Steinmann; Jan Buer; Peter-Michael Rath; Joerg Steinmann
Journal:  Mycoses       Date:  2016-01-25       Impact factor: 4.377

8.  Echinocandin and triazole antifungal susceptibility profiles for clinical opportunistic yeast and mold isolates collected from 2010 to 2011: application of new CLSI clinical breakpoints and epidemiological cutoff values for characterization of geographic and temporal trends of antifungal resistance.

Authors:  Michael A Pfaller; Shawn A Messer; Leah N Woosley; Ronald N Jones; Mariana Castanheira
Journal:  J Clin Microbiol       Date:  2013-05-29       Impact factor: 5.948

9.  Genetic Drivers of Multidrug Resistance in Candida glabrata.

Authors:  Kelley R Healey; Cristina Jimenez Ortigosa; Erika Shor; David S Perlin
Journal:  Front Microbiol       Date:  2016-12-15       Impact factor: 5.640

10.  Epidemiology and Risk Factors for Echinocandin Nonsusceptible Candida glabrata Bloodstream Infections: Data From a Large Multisite Population-Based Candidemia Surveillance Program, 2008-2014.

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  15 in total

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2.  Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan.

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Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

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4.  Disclosing azole resistance mechanisms in resistant Candida glabrata strains encoding wild-type or gain-of-function CgPDR1 alleles through comparative genomics and transcriptomics.

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Journal:  G3 (Bethesda)       Date:  2022-07-06       Impact factor: 3.542

Review 5.  Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection.

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6.  Low Level of Antifungal Resistance in Iranian Isolates of Candida glabrata Recovered from Blood Samples in a Multicenter Study from 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of PDR1.

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7.  The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulence and Azole Resistance.

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Review 8.  Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium.

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Review 9.  Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata.

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10.  Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: Fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure.

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Journal:  Mycoses       Date:  2020-08-05       Impact factor: 4.377
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