Sarah Weinberger1, Carola Klarholz-Pevere1, Lutz Liefeldt2, Michael Baeder3, Nico Steckhan4, Frank Friedersdorff5. 1. Department of Urology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. 2. Department of Nephrology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. 3. Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. 4. Department of Internal and Complementary Medicine, Immanuel Hospital and Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. 5. Department of Urology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. frank.friedersdorff@charite.de.
Abstract
PURPOSE: To analyse the influence of CT-based depth correction in the assessment of split renal function in potential living kidney donors. METHODS: In 116 consecutive living kidney donors preoperative split renal function was assessed using the CT-based depth correction. Influence on donor side selection and postoperative renal function of the living kidney donors were analyzed. Linear regression analysis was performed to identify predictors of postoperative renal function. RESULTS: A left versus right kidney depth variation of more than 1 cm was found in 40/114 donors (35%). 11 patients (10%) had a difference of more than 5% in relative renal function after depth correction. Kidney depth variation and changes in relative renal function after depth correction would have had influence on side selection in 30 of 114 living kidney donors. CT depth correction did not improve the predictability of postoperative renal function of the living kidney donor. In general, it was not possible to predict the postoperative renal function from preoperative total and relative renal function. In multivariate linear regression analysis, age and BMI were identified as most important predictors for postoperative renal function of the living kidney donors. CONCLUSIONS: Our results clearly indicate that concerning the postoperative renal function of living kidney donors, the relative renal function of the donated kidney seems to be less important than other factors. A multimodal assessment with consideration of all available results including kidney size, location of the kidney and split renal function remains necessary.
PURPOSE: To analyse the influence of CT-based depth correction in the assessment of split renal function in potential living kidney donors. METHODS: In 116 consecutive living kidney donors preoperative split renal function was assessed using the CT-based depth correction. Influence on donor side selection and postoperative renal function of the living kidney donors were analyzed. Linear regression analysis was performed to identify predictors of postoperative renal function. RESULTS: A left versus right kidney depth variation of more than 1 cm was found in 40/114 donors (35%). 11 patients (10%) had a difference of more than 5% in relative renal function after depth correction. Kidney depth variation and changes in relative renal function after depth correction would have had influence on side selection in 30 of 114 living kidney donors. CT depth correction did not improve the predictability of postoperative renal function of the living kidney donor. In general, it was not possible to predict the postoperative renal function from preoperative total and relative renal function. In multivariate linear regression analysis, age and BMI were identified as most important predictors for postoperative renal function of the living kidney donors. CONCLUSIONS: Our results clearly indicate that concerning the postoperative renal function of living kidney donors, the relative renal function of the donated kidney seems to be less important than other factors. A multimodal assessment with consideration of all available results including kidney size, location of the kidney and split renal function remains necessary.
Entities:
Keywords:
Depth correction of renal scintigraphy; Living kidney donation; Split renal function
Authors: A Prigent; P Cosgriff; G F Gates; G Granerus; E J Fine; K Itoh; M Peters; A Piepsz; M Rehling; M Rutland; A Taylor Journal: Semin Nucl Med Date: 1999-04 Impact factor: 4.446
Authors: F Engelken; F Friedersdorff; T F Fuller; A Magheli; K Budde; F Halleck; S Deger; L Liefeldt; B Hamm; M Giessing; G Diederichs Journal: World J Urol Date: 2013-01-08 Impact factor: 4.226
Authors: Miki N Hew; Dedan Opondo; Ernesto R Cordeiro; Karlijn A M I van Donselaar-van der Pant; Frederike J Bemelman; Mirza M Idu; Jean J M C H de la Rosette; M Pilar Laguna Journal: BJU Int Date: 2013-10-31 Impact factor: 5.588
Authors: Sarah Weinberger; Michael Baeder; Christian Scheurig-Muenkler; Ingo Guenter Steffen; Ahmed Magheli; Kurt Miller; Carsten Kempkensteffen Journal: J Nephrol Date: 2015-08-19 Impact factor: 3.902