Literature DB >> 29556104

Structural basis for backbone N-methylation by an interrupted adenylation domain.

Shogo Mori1, Allan H Pang1, Taylor A Lundy1, Atefeh Garzan1, Oleg V Tsodikov2, Sylvie Garneau-Tsodikova3.   

Abstract

Interrupted adenylation domains are enigmatic fusions, in which one enzyme is inserted into another to form a highly unusual bifunctional enzyme. We present the first crystal structure of an interrupted adenylation domain that reveals a unique embedded methyltransferase. The structure and functional data provide insight into how these enzymes N-methylate amino acid precursors en route to nonribosomal peptides.

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Year:  2018        PMID： 29556104     DOI： 10.1038/s41589-018-0014-7

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  16 in total

1.  Alanine Scanning of YbdZ, an MbtH-like Protein, Reveals Essential Residues for Functional Interactions with Its Nonribosomal Peptide Synthetase Partner EntF.

Authors:  Rebecca A Schomer; Hyunjun Park; John J Barkei; Michael G Thomas
Journal:  Biochemistry       Date:  2018-07-03       Impact factor: 3.162

Review 2.  Refining and expanding nonribosomal peptide synthetase function and mechanism.

Authors:  Matt McErlean; Jonathan Overbay; Steven Van Lanen
Journal:  J Ind Microbiol Biotechnol       Date:  2019-01-23       Impact factor: 3.346

3.  Using MbtH-Like Proteins to Alter the Substrate Profile of a Nonribosomal Peptide Adenylation Enzyme.

Authors:  Shogo Mori; Keith D Green; Ryan Choi; Garry W Buchko; Michael G Fried; Sylvie Garneau-Tsodikova
Journal:  Chembiochem       Date:  2018-10-04       Impact factor: 3.164

Review 4.  Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations.

Authors:  Diego A Alonzo; T Martin Schmeing
Journal:  Protein Sci       Date:  2020-11-02       Impact factor: 6.725

5.  Stuffed Methyltransferase Catalyzes the Penultimate Step of Pyochelin Biosynthesis.

Authors:  Trey A Ronnebaum; Jeffrey S McFarlane; Thomas E Prisinzano; Squire J Booker; Audrey L Lamb
Journal:  Biochemistry       Date:  2018-12-27       Impact factor: 3.162

6.  Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis.

Authors:  Diego A Alonzo; Clarisse Chiche-Lapierre; Michael J Tarry; Jimin Wang; T Martin Schmeing
Journal:  Nat Chem Biol       Date:  2020-02-17       Impact factor: 15.040

Review 7.  The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities.

Authors:  Sarah Bonhomme; Andréa Dessen; Pauline Macheboeuf
Journal:  Open Biol       Date:  2021-05-26       Impact factor: 6.411

8.  Lessons learned in engineering interrupted adenylation domains when attempting to create trifunctional enzymes from three independent monofunctional ones.

Authors:  Taylor A Lundy; Shogo Mori; Sylvie Garneau-Tsodikova
Journal:  RSC Adv       Date:  2020-09-15       Impact factor: 4.036

9.  Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi.

Authors:  Reto D Zwahlen; Carsten Pohl; Roel A L Bovenberg; Arnold J M Driessen
Journal:  ACS Synth Biol       Date:  2019-07-16       Impact factor: 5.110

10.  Modified substrate specificity of a methyltransferase domain by protein insertion into an adenylation domain of the bassianolide synthetase.

Authors:  Fuchao Xu; Russell Butler; Kyle May; Megi Rexhepaj; Dayu Yu; Jiachen Zi; Yi Chen; Yonghong Liang; Jia Zeng; Joan Hevel; Jixun Zhan
Journal:  J Biol Eng       Date:  2019-07-31       Impact factor: 4.355
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