Emily L Graczyk1, Benoit P Delhaye, Matthew A Schiefer, Sliman J Bensmaia, Dustin J Tyler. 1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, United States of America. Cleveland Louis Stokes Department of Veteran's Affairs Medical Center, Cleveland, OH 44106, United States of America.
Abstract
OBJECTIVE: Sensory systems adapt their sensitivity to ambient stimulation levels to improve their responsiveness to changes in stimulation. The sense of touch is also subject to adaptation, as evidenced by the desensitization produced by prolonged vibratory stimulation of the skin. Electrical stimulation of nerves elicits tactile sensations that can convey feedback for bionic limbs. In this study, we investigate whether artificial touch is also subject to adaptation, despite the fact that the peripheral mechanotransducers are bypassed. APPROACH: Using well-established psychophysical paradigms, we characterize the time course and magnitude of sensory adaptation caused by extended electrical stimulation of the residual somatosensory nerves in three human amputees implanted with cuff electrodes. MAIN RESULTS: We find that electrical stimulation of the nerve also induces perceptual adaptation that recovers after cessation of the stimulus. The time course and magnitude of electrically-induced adaptation are equivalent to their mechanically-induced counterparts. SIGNIFICANCE: We conclude that, in natural touch, the process of mechanotransduction is not required for adaptation, and artificial touch naturally experiences adaptation-induced adjustments of the dynamic range of sensations. Further, as it does for native hands, adaptation confers to bionic hands enhanced sensitivity to changes in stimulation and thus a more natural sensory experience.
OBJECTIVE: Sensory systems adapt their sensitivity to ambient stimulation levels to improve their responsiveness to changes in stimulation. The sense of touch is also subject to adaptation, as evidenced by the desensitization produced by prolonged vibratory stimulation of the skin. Electrical stimulation of nerves elicits tactile sensations that can convey feedback for bionic limbs. In this study, we investigate whether artificial touch is also subject to adaptation, despite the fact that the peripheral mechanotransducers are bypassed. APPROACH: Using well-established psychophysical paradigms, we characterize the time course and magnitude of sensory adaptation caused by extended electrical stimulation of the residual somatosensory nerves in three human amputees implanted with cuff electrodes. MAIN RESULTS: We find that electrical stimulation of the nerve also induces perceptual adaptation that recovers after cessation of the stimulus. The time course and magnitude of electrically-induced adaptation are equivalent to their mechanically-induced counterparts. SIGNIFICANCE: We conclude that, in natural touch, the process of mechanotransduction is not required for adaptation, and artificial touch naturally experiences adaptation-induced adjustments of the dynamic range of sensations. Further, as it does for native hands, adaptation confers to bionic hands enhanced sensitivity to changes in stimulation and thus a more natural sensory experience.
Authors: Emily L Graczyk; Matthew A Schiefer; Hannes P Saal; Benoit P Delhaye; Sliman J Bensmaia; Dustin J Tyler Journal: Sci Transl Med Date: 2016-10-26 Impact factor: 17.956
Authors: B L Whitsel; E F Kelly; M Quibrera; M Tommerdahl; Y Li; O V Favorov; M Xu; C B Metz Journal: Somatosens Mot Res Date: 2003 Impact factor: 1.111
Authors: G Valle; F M Petrini; I Strauss; F Iberite; E D'Anna; G Granata; M Controzzi; C Cipriani; T Stieglitz; P M Rossini; A Mazzoni; S Raspopovic; S Micera Journal: Sci Rep Date: 2018-11-12 Impact factor: 4.379