| Literature DB >> 29549549 |
MacKinsey A Christian1,2, Maureen Samms-Vaughan3, MinJae Lee2,4, Jan Bressler5, Manouchehr Hessabi2, Megan L Grove5, Sydonnie Shakespeare-Pellington3, Charlene Coore Desai3, Jody-Ann Reece3, Katherine A Loveland6, Eric Boerwinkle5,7, Mohammad H Rahbar8,9,10.
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.Entities:
Keywords: Autism spectrum disorder; Fever; Jamaica; Pesticides; Physical trauma; Volatile organic compounds
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Year: 2018 PMID： 29549549 PMCID： PMC6041149 DOI： 10.1007/s10803-018-3537-6
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257