Literature DB >> 29536312

Study of Biodistribution of the Modular Nanotransporters after Systemic Administration in Murine Cloudman S91 Melanoma Model.

Y V Khramtsov1, A V Ulasov1, A A Rosenkranz1,2, G P Georgiev1, A S Sobolev3,4.   

Abstract

The distribution of modular nanotransporters (MNTs) that are used to deliver drugs into melanoma cell nuclei after their intravenous administration into mice with Cloudman S91 melanoma was studied. The modification of MNTs with polyethylene glycol (PEG) of different length and their administration during the treatment with docetaxel, nitroglycerin, and excess of nonspecific MNTs leads to an improved accumulation of MNTs in the tummor. Among the variants studied, the MNT with attached PEG with Mr 40 kDa exhibited the best properties.

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Year:  2018        PMID： 29536312     DOI： 10.1134/S1607672918010131

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

1.  Antitumor efficacy of Auger electron emitter 111In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression.

Authors:  A A Rosenkranz; T A Slastnikova; Yu V Khramtsov; T S Karyagina; G P Georgiev; A S Sobolev
Journal:  Dokl Biochem Biophys       Date:  2017-05-17       Impact factor: 0.788

2.  A mechanistic compartmental model for total antibody uptake in tumors.

Authors:  Greg M Thurber; K Dane Wittrup
Journal:  J Theor Biol       Date:  2012-09-06       Impact factor: 2.691

Review 3.  Process for protein PEGylation.

Authors:  David Pfister; Massimo Morbidelli
Journal:  J Control Release       Date:  2014-02-14       Impact factor: 9.776

Review 4.  Chemotherapy-associated hepatotoxicity: how concerned should we be?

Authors:  Thomas A Aloia; Bridget N Fahy
Journal:  Expert Rev Anticancer Ther       Date:  2010-04       Impact factor: 4.512

5.  Characterization of receptors for alpha-melanocyte-stimulating hormone on human melanoma cells.

Authors:  W Siegrist; F Solca; S Stutz; L Giuffrè; S Carrel; J Girard; A N Eberle
Journal:  Cancer Res       Date:  1989-11-15       Impact factor: 12.701

6.  A biodistribution study of solid lipid-polyethyleneimine hybrid nanocarrier for cancer RNAi therapy.

Authors:  Hui Yi Xue; Ngoc Tran; Ho Lun Wong
Journal:  Eur J Pharm Biopharm       Date:  2016-08-26       Impact factor: 5.571

7.  Study of efficiency of the modular nanotransporter for targeted delivery of photosensitizers to melanoma cell nuclei in vivo.

Authors:  T A Slastnikova; A A Rosenkranz; T N Lupanova; P V Gulak; N V Gnuchev; A S Sobolev
Journal:  Dokl Biochem Biophys       Date:  2012-11-07       Impact factor: 0.788

8.  Application of vasoactive and matrix-modifying drugs can improve polyplex delivery to tumors upon intravenous administration.

Authors:  Mikhail O Durymanov; Alexey V Yarutkin; Dmitry V Bagrov; Dmitry V Klinov; Alexander V Kedrov; Nikolay K Chemeris; Andrey A Rosenkranz; Alexander S Sobolev
Journal:  J Control Release       Date:  2016-04-09       Impact factor: 9.776

9.  Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Yuri V Khramtsov; Tatiana S Karyagina; Sergey A Ovechko; Alexander S Sobolev
Journal:  Drug Des Devel Ther       Date:  2017-04-26       Impact factor: 4.162

10.  Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Natalia B Morozova; Maria S Vorontsova; Vasiliy M Petriev; Tatiana N Lupanova; Alexey V Ulasov; Michael R Zalutsky; Raisa I Yakubovskaya; Alexander S Sobolev
Journal:  Int J Nanomedicine       Date:  2017-01-10
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  2 in total

1.  Stabilization of Modular Nanotransporters by Embedding Hemin in Them in a New Strain with Heme Receptor Expression.

Authors:  Yu V Khramtsov; A V Ulasov; A A Rosenkranz; G P Georgiev; A S Sobolev
Journal:  Dokl Biochem Biophys       Date:  2020-04-27       Impact factor: 0.788

2.  Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression.

Authors:  Andrey A Rosenkranz; Tatiana A Slastnikova; Tatiana A Karmakova; Maria S Vorontsova; Natalia B Morozova; Vasiliy M Petriev; Alexey S Abrosimov; Yuri V Khramtsov; Tatiana N Lupanova; Alexey V Ulasov; Raisa I Yakubovskaya; Georgii P Georgiev; Alexander S Sobolev
Journal:  Front Pharmacol       Date:  2018-11-19       Impact factor: 5.810
  2 in total

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