Literature DB >> 32342313

Stabilization of Modular Nanotransporters by Embedding Hemin in Them in a New Strain with Heme Receptor Expression.

Yu V Khramtsov1, A V Ulasov1, A A Rosenkranz1,2, G P Georgiev1, A S Sobolev3,4.   

Abstract

It was found that the use of a new strain-producer Escherichia coli, expressing the heme receptor ChuA, enables obtaining a hemin-containing modular nanotransporter (MNT) for drug delivery into the nuclei of target cells. The hemin-containing MNT becomes stabilized, which leads to an increase in its thermal stability and prevents aggregation of this protein.

Entities:  

Keywords:  aggregates; heme embedding; modular nanotransporters; thermal stability

Year:  2020        PMID： 32342313     DOI： 10.1134/S1607672920010093

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  11 in total

1.  Modular drug transporters with diphtheria toxin translocation domain form edged holes in lipid membranes.

Authors:  Yuri V Khramtsov; Tatyana I Rokitskaya; Andrey A Rosenkranz; Georgiy A Trusov; Nikolay V Gnuchev; Yuri N Antonenko; Alexander S Sobolev
Journal:  J Control Release       Date:  2008-03-19       Impact factor: 9.776

2.  Study of Biodistribution of the Modular Nanotransporters after Systemic Administration in Murine Cloudman S91 Melanoma Model.

Authors:  Y V Khramtsov; A V Ulasov; A A Rosenkranz; G P Georgiev; A S Sobolev
Journal:  Dokl Biochem Biophys       Date:  2018-03-14       Impact factor: 0.788

3.  Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin.

Authors:  Ryan A Helmick; Arin E Fletcher; Anne M Gardner; Christopher R Gessner; Angela N Hvitved; Michael C Gustin; Paul R Gardner
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

4.  Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic.

Authors:  Eftychia Koumarianou; Tatiana A Slastnikova; Marek Pruszynski; Andrey A Rosenkranz; Ganesan Vaidyanathan; Alexander S Sobolev; Michael R Zalutsky
Journal:  Nucl Med Biol       Date:  2014-04-02       Impact factor: 2.408

Review 5.  Structural and thermodynamic consequences of b heme binding for monomeric apoglobins and other apoproteins.

Authors:  Daniel A Landfried; David A Vuletich; Matthew P Pond; Juliette T J Lecomte
Journal:  Gene       Date:  2007-05-01       Impact factor: 3.688

6.  System for the expression of recombinant hemoproteins in Escherichia coli.

Authors:  Cornelius L Varnado; Douglas C Goodwin
Journal:  Protein Expr Purif       Date:  2004-05       Impact factor: 1.650

7.  Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Yuri V Khramtsov; Tatiana S Karyagina; Sergey A Ovechko; Alexander S Sobolev
Journal:  Drug Des Devel Ther       Date:  2017-04-26       Impact factor: 4.162

Review 8.  Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters.

Authors:  Alexander S Sobolev
Journal:  Front Pharmacol       Date:  2018-08-27       Impact factor: 5.810

9.  Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I.

Authors:  Tatiana A Slastnikova; Eftychia Koumarianou; Andrey A Rosenkranz; Ganesan Vaidyanathan; Tatiana N Lupanova; Alexander S Sobolev; Michael R Zalutsky
Journal:  EJNMMI Res       Date:  2012-10-29       Impact factor: 3.138

Review 10.  Immunogenicity of therapeutic proteins: influence of aggregation.

Authors:  Kirsty D Ratanji; Jeremy P Derrick; Rebecca J Dearman; Ian Kimber
Journal:  J Immunotoxicol       Date:  2013-08-06       Impact factor: 3.000
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