Literature DB >> 28510138

Antitumor efficacy of Auger electron emitter 111In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression.

A A Rosenkranz1,2, T A Slastnikova1, Yu V Khramtsov1, T S Karyagina1, G P Georgiev1, A S Sobolev3,4.   

Abstract

A new modular nanotransporter (MNT) for the delivery of anticancer agents into the nuclei of cells with folate receptor overexpression was created. An effective method for acceding labeling of this MNT with Auger electron emitter 111In has been developed. A significant therapeutic effect was observed after a single intratumoral injection of the new 111In-labeled MNT to mice grafted with human cervical carcinoma characterized by folate receptor overexpression.

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Year:  2017        PMID： 28510138     DOI： 10.1134/S1607672917020016

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  6 in total

1.  Radiometal-labeled agents (non-technetium) for diagnostic imaging.

Authors:  C J Anderson; M J Welch
Journal:  Chem Rev       Date:  1999-09-08       Impact factor: 60.622

Review 2.  Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Michael R Zalutsky; Alexander S Sobolev
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

3.  Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay.

Authors:  Nikki Parker; Mary Jo Turk; Elaine Westrick; Jeffrey D Lewis; Philip S Low; Christopher P Leamon
Journal:  Anal Biochem       Date:  2005-03-15       Impact factor: 3.365

4.  Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic.

Authors:  Eftychia Koumarianou; Tatiana A Slastnikova; Marek Pruszynski; Andrey A Rosenkranz; Ganesan Vaidyanathan; Alexander S Sobolev; Michael R Zalutsky
Journal:  Nucl Med Biol       Date:  2014-04-02       Impact factor: 2.408

Review 5.  Targeting the nucleus: an overview of Auger-electron radionuclide therapy.

Authors:  Bart Cornelissen; Katherine A Vallis
Journal:  Curr Drug Discov Technol       Date:  2010-12

6.  Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I.

Authors:  Tatiana A Slastnikova; Eftychia Koumarianou; Andrey A Rosenkranz; Ganesan Vaidyanathan; Tatiana N Lupanova; Alexander S Sobolev; Michael R Zalutsky
Journal:  EJNMMI Res       Date:  2012-10-29       Impact factor: 3.138
  6 in total
  5 in total

1.  Study of Biodistribution of the Modular Nanotransporters after Systemic Administration in Murine Cloudman S91 Melanoma Model.

Authors:  Y V Khramtsov; A V Ulasov; A A Rosenkranz; G P Georgiev; A S Sobolev
Journal:  Dokl Biochem Biophys       Date:  2018-03-14       Impact factor: 0.788

2.  Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression.

Authors:  Andrey A Rosenkranz; Tatiana A Slastnikova; Tatiana A Karmakova; Maria S Vorontsova; Natalia B Morozova; Vasiliy M Petriev; Alexey S Abrosimov; Yuri V Khramtsov; Tatiana N Lupanova; Alexey V Ulasov; Raisa I Yakubovskaya; Georgii P Georgiev; Alexander S Sobolev
Journal:  Front Pharmacol       Date:  2018-11-19       Impact factor: 5.810

Review 3.  Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters.

Authors:  Alexander S Sobolev
Journal:  Front Pharmacol       Date:  2018-08-27       Impact factor: 5.810

Review 4.  Targeted Intracellular Delivery of Antibodies: The State of the Art.

Authors:  Tatiana A Slastnikova; A V Ulasov; A A Rosenkranz; A S Sobolev
Journal:  Front Pharmacol       Date:  2018-10-24       Impact factor: 5.810

5.  The Delivery of Biologically Active Agents into the Nuclei of Target Cells for the Purposes of Translational Medicine.

Authors:  A S Sobolev
Journal:  Acta Naturae       Date:  2020 Oct-Dec       Impact factor: 1.845
  5 in total

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