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Literature DB >> 29528686

Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications.

Josef R Bober¹, Chase L Beisel², Nikhil U Nair¹.

Abstract

An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies.

Entities: Chemical Disease Gene Species

Keywords: CRISPR; genetic tools; genome engineering; microbiome; probiotics

Mesh：

Substances：
Lactic Acid

Year: 2018 PMID： 29528686 PMCID： PMC6100750 DOI： 10.1146/annurev-bioeng-062117-121019

Source DB: PubMed Journal: Annu Rev Biomed Eng ISSN： 1523-9829 Impact factor: 9.590

145 in total

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Journal: Bioengineered Date: 2015-04-16 Impact factor: 3.269

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Journal: Nat Biotechnol Date: 2014-09-21 Impact factor: 54.908

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Journal: Nat Biotechnol Date: 2014-10-05 Impact factor: 54.908

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Journal: Front Microbiol Date: 2015-10-06 Impact factor: 5.640

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Authors: Wenyan Jiang; David Bikard; David Cox; Feng Zhang; Luciano A Marraffini
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Journal: Microb Cell Fact Date: 2016-05-03 Impact factor: 5.328

26 in total

Review 1. Development of bacteria as diagnostics and therapeutics by genetic engineering.

Authors: Daejin Lim; Miryoung Song
Journal: J Microbiol Date: 2019-05-11 Impact factor: 3.422

Review 2. Engineering microbial diagnostics and therapeutics with smart control.

Authors: Matthew B Amrofell; Austin G Rottinghaus; Tae Seok Moon
Journal: Curr Opin Biotechnol Date: 2020-06-18 Impact factor: 9.740

3. A Tunable and Expandable Transactivation System in Probiotic Yeast Saccharomyces boulardii.

Authors: Suryang Kwak; Bejan Mahmud; Gautam Dantas
Journal: ACS Synth Biol Date: 2021-12-23 Impact factor: 5.249

4. Beneficial effect of probiotics on Pseudomonas aeruginosa-infected intestinal epithelial cells through inflammatory IL-8 and antimicrobial peptide human beta-defensin-2 modulation.

Authors: Fu-Chen Huang; Yi-Ting Lu; Yu-Hsuan Liao
Journal: Innate Immun Date: 2020-09-28 Impact factor: 2.680