G Conte1, S Milani2, G Palumbo3, G Talenti4, S Boito5, M Rustico6, F Triulzi3,7, A Righini8, G Izzo8, C Doneda8, A Zolin2, C Parazzini8. 1. From the Neuroradiology Unit (G.C.,G.P., F.T.) giorgioconte.unimed@gmail.com. 2. Department of Clinical Sciences and Community Health (S.M., A.Z.), Laboratory of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro,". 3. From the Neuroradiology Unit (G.C.,G.P., F.T.). 4. Neuroradiology Unit (G.T.), Padua University Hospital, Padua, Italy. 5. Division of Prenatal Diagnosis (S.B.), Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Ca' Granda Ospedale Policlinico, Milan, Italy. 6. Fetal Therapy Unit "Umberto Nicolini" (M.R.), Department of Woman Mother and Neonate. 7. Department of Pathophysiology and Transplantation (F.T.), Università degli Studi di Milano, Milan, Italy. 8. Department of Paediatric Radiology and Neuroradiology (A.R., G.I., C.D., C.P.), Ospedale dei Bambini "V. Buzzi," Milan, Italy.
Abstract
BACKGROUND AND PURPOSE: Evaluation of biometry is a fundamental step in prenatal brain MR imaging. While different studies have reported reference centiles for MR imaging biometric data of fetuses in the late second and third trimesters of gestation, no one has reported them in fetuses in the early second trimester. We report centiles of normal MR imaging linear biometric data of a large cohort of fetal brains within 24 weeks of gestation. MATERIALS AND METHODS: From the data bases of 2 referral centers of fetal medicine, accounting for 3850 examinations, we retrospectively collected 169 prenatal brain MR imaging examinations of singleton pregnancies, between 20 and 24 weeks of gestational age, with normal brain anatomy at MR imaging and normal postnatal neurologic development. To trace the reference centiles, we used the CG-LMS method. RESULTS: Reference biometric centiles for the developing structures of the cerebrum, cerebellum, brain stem, and theca were obtained. The overall interassessor agreement was adequate for all measurements. CONCLUSIONS: Reference biometric centiles of the brain structures in fetuses between 20 and 24 weeks of gestational age may be a reliable tool in assessing fetal brain development.
BACKGROUND AND PURPOSE: Evaluation of biometry is a fundamental step in prenatal brain MR imaging. While different studies have reported reference centiles for MR imaging biometric data of fetuses in the late second and third trimesters of gestation, no one has reported them in fetuses in the early second trimester. We report centiles of normal MR imaging linear biometric data of a large cohort of fetal brains within 24 weeks of gestation. MATERIALS AND METHODS: From the data bases of 2 referral centers of fetal medicine, accounting for 3850 examinations, we retrospectively collected 169 prenatal brain MR imaging examinations of singleton pregnancies, between 20 and 24 weeks of gestational age, with normal brain anatomy at MR imaging and normal postnatal neurologic development. To trace the reference centiles, we used the CG-LMS method. RESULTS: Reference biometric centiles for the developing structures of the cerebrum, cerebellum, brain stem, and theca were obtained. The overall interassessor agreement was adequate for all measurements. CONCLUSIONS: Reference biometric centiles of the brain structures in fetuses between 20 and 24 weeks of gestational age may be a reliable tool in assessing fetal brain development.
Authors: G O Dovjak; V Schmidbauer; P C Brugger; G M Gruber; M Diogo; S Glatter; M Weber; B Ulm; D Prayer; G J Kasprian Journal: Ultrasound Obstet Gynecol Date: 2021-07-06 Impact factor: 7.299