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Literature DB >> 29507396

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma.

Cun Wang^1,2, Haojie Jin², Dongmei Gao³, Liqin Wang¹, Bastiaan Evers¹, Zheng Xue¹, Guangzhi Jin⁴, Cor Lieftink¹, Roderick L Beijersbergen¹, Wenxin Qin⁵, René Bernards⁶.

Abstract

Entities: Disease Gene

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Year: 2018 PMID： 29507396 PMCID： PMC5993748 DOI： 10.1038/s41422-018-0020-z

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

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12 in total

1. CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

Authors: Bastiaan Evers; Katarzyna Jastrzebski; Jeroen P M Heijmans; Wipawadee Grernrum; Roderick L Beijersbergen; Rene Bernards
Journal: Nat Biotechnol Date: 2016-04-25 Impact factor: 54.908

2. Genome-scale CRISPR-Cas9 knockout screening in human cells.

Authors: Ophir Shalem; Neville E Sanjana; Ella Hartenian; Xi Shi; David A Scott; Tarjei Mikkelson; Dirk Heckl; Benjamin L Ebert; David E Root; John G Doench; Feng Zhang
Journal: Science Date: 2013-12-12 Impact factor: 47.728

Review 3. Hepatocellular carcinoma.

Authors: Josep M Llovet; Jessica Zucman-Rossi; Eli Pikarsky; Bruno Sangro; Myron Schwartz; Morris Sherman; Gregory Gores
Journal: Nat Rev Dis Primers Date: 2016-04-14 Impact factor: 52.329

Review 4. Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.

Authors: Jessica Zucman-Rossi; Augusto Villanueva; Jean-Charles Nault; Josep M Llovet
Journal: Gastroenterology Date: 2015-06-20 Impact factor: 22.682

5. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

Authors: Edmond Chipumuro; Eugenio Marco; Camilla L Christensen; Nicholas Kwiatkowski; Tinghu Zhang; Clark M Hatheway; Brian J Abraham; Bandana Sharma; Caleb Yeung; Abigail Altabef; Antonio Perez-Atayde; Kwok-Kin Wong; Guo-Cheng Yuan; Nathanael S Gray; Richard A Young; Rani E George
Journal: Cell Date: 2014-11-06 Impact factor: 41.582

6. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.

Authors: Camilla L Christensen; Nicholas Kwiatkowski; Brian J Abraham; Julian Carretero; Fatima Al-Shahrour; Tinghu Zhang; Edmond Chipumuro; Grit S Herter-Sprie; Esra A Akbay; Abigail Altabef; Jianming Zhang; Takeshi Shimamura; Marzia Capelletti; Jakob B Reibel; Jillian D Cavanaugh; Peng Gao; Yan Liu; Signe R Michaelsen; Hans S Poulsen; Amir R Aref; David A Barbie; James E Bradner; Rani E George; Nathanael S Gray; Richard A Young; Kwok-Kin Wong
Journal: Cancer Cell Date: 2014-12-08 Impact factor: 31.743

7. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial.

Authors: Ann-Lii Cheng; Yoon-Koo Kang; Zhendong Chen; Chao-Jung Tsao; Shukui Qin; Jun Suk Kim; Rongcheng Luo; Jifeng Feng; Shenglong Ye; Tsai-Sheng Yang; Jianming Xu; Yan Sun; Houjie Liang; Jiwei Liu; Jiejun Wang; Won Young Tak; Hongming Pan; Karin Burock; Jessie Zou; Dimitris Voliotis; Zhongzhen Guan
Journal: Lancet Oncol Date: 2008-12-16 Impact factor: 41.316

8. CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Authors: Yubao Wang; Tinghu Zhang; Nicholas Kwiatkowski; Brian J Abraham; Tong Ihn Lee; Shaozhen Xie; Haluk Yuzugullu; Thanh Von; Heyuan Li; Ziao Lin; Daniel G Stover; Elgene Lim; Zhigang C Wang; J Dirk Iglehart; Richard A Young; Nathanael S Gray; Jean J Zhao
Journal: Cell Date: 2015-09-24 Impact factor: 41.582

9. Sorafenib in advanced hepatocellular carcinoma.

Authors: Josep M Llovet; Sergio Ricci; Vincenzo Mazzaferro; Philip Hilgard; Edward Gane; Jean-Frédéric Blanc; Andre Cosme de Oliveira; Armando Santoro; Jean-Luc Raoul; Alejandro Forner; Myron Schwartz; Camillo Porta; Stefan Zeuzem; Luigi Bolondi; Tim F Greten; Peter R Galle; Jean-François Seitz; Ivan Borbath; Dieter Häussinger; Tom Giannaris; Minghua Shan; Marius Moscovici; Dimitris Voliotis; Jordi Bruix
Journal: N Engl J Med Date: 2008-07-24 Impact factor: 91.245

10. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Authors: Nicholas Kwiatkowski; Tinghu Zhang; Peter B Rahl; Brian J Abraham; Jessica Reddy; Scott B Ficarro; Anahita Dastur; Arnaud Amzallag; Sridhar Ramaswamy; Bethany Tesar; Catherine E Jenkins; Nancy M Hannett; Douglas McMillin; Takaomi Sanda; Taebo Sim; Nam Doo Kim; Thomas Look; Constantine S Mitsiades; Andrew P Weng; Jennifer R Brown; Cyril H Benes; Jarrod A Marto; Richard A Young; Nathanael S Gray
Journal: Nature Date: 2014-06-22 Impact factor: 49.962

14 in total

1. Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen.

Authors: Kseniya Glinkina; Arwin Groenewoud; Amina F A S Teunisse; B Ewa Snaar-Jagalska; Aart G Jochemsen
Journal: Cancers (Basel) Date: 2022-06-29 Impact factor: 6.575

Review 2. CRISPR Technology in Cancer Diagnosis and Treatment: Opportunities and Challenges.

Authors: Behrouz Shademan; Sepideh Masjedi; Vahidreza Karamad; Alireza Isazadeh; Fatma Sogutlu; Mohammad Hosein Saeedi Rad; Alireza Nourazarian
Journal: Biochem Genet Date: 2022-01-29 Impact factor: 2.220

3. Targeting CDK7 increases the stability of Snail to promote the dissemination of colorectal cancer.

Authors: Yan Zhou; Linlin Lu; Guanmin Jiang; Zhuojia Chen; Jiexin Li; Panpan An; Likun Chen; Jun Du; Hongsheng Wang
Journal: Cell Death Differ Date: 2018-11-19 Impact factor: 15.828

Review 4. Research on CRISPR/system in major cancers and its potential in cancer treatments.

Authors: Z Liu; Z Liao; Y Chen; L Zhou; W Huangting; H Xiao
Journal: Clin Transl Oncol Date: 2020-07-15 Impact factor: 3.405

Review 5. Exploring liver cancer biology through functional genetic screens.

Authors: Cun Wang; Ying Cao; Chen Yang; René Bernards; Wenxin Qin
Journal: Nat Rev Gastroenterol Hepatol Date: 2021-06-23 Impact factor: 46.802

Review 6. Therapeutic targeting of transcriptional cyclin-dependent kinases.

Authors: Matthew D Galbraith; Heather Bender; Joaquín M Espinosa
Journal: Transcription Date: 2018-11-09

7. Inducing and exploiting vulnerabilities for the treatment of liver cancer.

Authors: Cun Wang; Serena Vegna; Haojie Jin; Bente Benedict; Cor Lieftink; Christel Ramirez; Rodrigo Leite de Oliveira; Ben Morris; Jules Gadiot; Wei Wang; Aimée du Chatinier; Liqin Wang; Dongmei Gao; Bastiaan Evers; Guangzhi Jin; Zheng Xue; Arnout Schepers; Fleur Jochems; Antonio Mulero Sanchez; Sara Mainardi; Hein Te Riele; Roderick L Beijersbergen; Wenxin Qin; Leila Akkari; René Bernards
Journal: Nature Date: 2019-10-02 Impact factor: 49.962