Samuel Han1, Boskey Patel2, May Min2, Lisa Bocelli3, Joan Kheder3, Amy Wachholtz4, Wahid Wassef3. 1. Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Aurora, CO, USA. Electronic address: samuel.han@ucdenver.edu. 2. Department of Internal Medicine, University of Massachusetts Medical Center, Worcester, MA, USA. 3. Division of Gastroenterology, University of Massachusetts Medical Center, Worcester, MA, USA. 4. Department of Psychology, University of Colorado, Denver, CO, USA.
Abstract
OBJECTIVES: The aim of this study was to evaluate the impact of smoking on quality of life in patients with chronic pancreatitis. METHODS: This is a cross-sectional study of chronic pancreatitis patients followed at a single institution comparing smokers with non-smokers. The primary outcome was quality of life and secondary outcomes included demographics, drug and alcohol use, anxiety and depression, pain level, nutritional status, and metabolic factors. RESULTS: 48 smokers and 45 non-smokers participated in this study. Smokers had a worse overall quality of life and higher rates of opioid addiction and depression than non-smokers. Smokers also had less racial diversity, lower education levels, and higher amounts of narcotic use than non-smokers. Furthermore, smokers had a lower BMI and a higher proportional use of pancreatic enzyme replacement therapy. Smoking was found to be independently associated with worse quality of life on multivariable regression. CONCLUSIONS: The worse overall quality of life and higher rates of depression and anxiety create cause for concern in chronic pancreatitis patients who smoke. Smoking cessation should be an important target in chronic pancreatitis patients. Multicenter, multiethnic studies are needed to further elucidate this relationship.
OBJECTIVES: The aim of this study was to evaluate the impact of smoking on quality of life in patients with chronic pancreatitis. METHODS: This is a cross-sectional study of chronic pancreatitispatients followed at a single institution comparing smokers with non-smokers. The primary outcome was quality of life and secondary outcomes included demographics, drug and alcohol use, anxiety and depression, pain level, nutritional status, and metabolic factors. RESULTS: 48 smokers and 45 non-smokers participated in this study. Smokers had a worse overall quality of life and higher rates of opioid addiction and depression than non-smokers. Smokers also had less racial diversity, lower education levels, and higher amounts of narcotic use than non-smokers. Furthermore, smokers had a lower BMI and a higher proportional use of pancreatic enzyme replacement therapy. Smoking was found to be independently associated with worse quality of life on multivariable regression. CONCLUSIONS: The worse overall quality of life and higher rates of depression and anxiety create cause for concern in chronic pancreatitispatients who smoke. Smoking cessation should be an important target in chronic pancreatitispatients. Multicenter, multiethnic studies are needed to further elucidate this relationship.
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