Awais Ahmed1, Amit N Anand2, Ishani Shah3, William Yakah3, Steven D Freedman3, Robert Thomas4, Sunil G Sheth3. 1. Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rabb 423, Boston, MA, USA. aahmed1@bidmc.harvard.edu. 2. Department of Medicine, Division of Pulmonology, St. Elizabeth Medical Center, Boston, MA, USA. 3. Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rabb 423, Boston, MA, USA. 4. Department of Medicine, Division of Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Abstract
BACKGROUND: Patients with chronic pancreatitis (CP) have poor quality of life (QOL). Sleep disorders affect QOL when associated with chronic pain and opioid use. Hence patients with CP may have unrecognized sleep disturbances. AIMS: The aim of the study was to evaluate sleep disturbances in CP and its impact on QOL. METHODS: Established CP patients were prospectively enrolled after exclusion of patients with co-morbidities known to negatively affect sleep and QOL. Three questionnaires were used to identify sleep disturbances, PROMISv1SF8, Insomnia Severity Index, and Epworth Sleepiness Scale, and one for restless leg syndrome (RLS). PANQOLI and SF12 questionnaires were used to evaluate QOL. Two blinded sleep pulmonologists evaluated the responses. QOL assessments were then analyzed in patients with and without sleep disturbances. RESULTS: Of 89 patients, 48 met exclusion criteria, 41 were eligible, and 28 completed the study. Twenty patients (71%) had sleep disturbances with significantly worse scores across all 3 sleep questionnaires and also had lower scores on both PANQOLI (50 vs 76, p = 0.002) and SF-12 (physical component 29.3 vs 53.9, p < 0.001; mental component 36.4 vs 46.1, p = 0.03). Eleven patients (39%) had RLS and sleep disturbances. CONCLUSION: In patients with established CP there was a high prevalence of sleep disturbances and RLS with worse QOL representing a potential therapeutic target to improve QOL.
BACKGROUND: Patients with chronic pancreatitis (CP) have poor quality of life (QOL). Sleep disorders affect QOL when associated with chronic pain and opioid use. Hence patients with CP may have unrecognized sleep disturbances. AIMS: The aim of the study was to evaluate sleep disturbances in CP and its impact on QOL. METHODS: Established CP patients were prospectively enrolled after exclusion of patients with co-morbidities known to negatively affect sleep and QOL. Three questionnaires were used to identify sleep disturbances, PROMISv1SF8, Insomnia Severity Index, and Epworth Sleepiness Scale, and one for restless leg syndrome (RLS). PANQOLI and SF12 questionnaires were used to evaluate QOL. Two blinded sleep pulmonologists evaluated the responses. QOL assessments were then analyzed in patients with and without sleep disturbances. RESULTS: Of 89 patients, 48 met exclusion criteria, 41 were eligible, and 28 completed the study. Twenty patients (71%) had sleep disturbances with significantly worse scores across all 3 sleep questionnaires and also had lower scores on both PANQOLI (50 vs 76, p = 0.002) and SF-12 (physical component 29.3 vs 53.9, p < 0.001; mental component 36.4 vs 46.1, p = 0.03). Eleven patients (39%) had RLS and sleep disturbances. CONCLUSION: In patients with established CP there was a high prevalence of sleep disturbances and RLS with worse QOL representing a potential therapeutic target to improve QOL.
Authors: Dhiraj Yadav; Lawrence Timmons; Joanne T Benson; Ross A Dierkhising; Suresh T Chari Journal: Am J Gastroenterol Date: 2011-09-27 Impact factor: 10.864
Authors: Timothy B Gardner; Douglas G Adler; Chris E Forsmark; Bryan G Sauer; Jason R Taylor; David C Whitcomb Journal: Am J Gastroenterol Date: 2020-03 Impact factor: 10.864
Authors: David C Whitcomb; Luca Frulloni; Pramod Garg; Julia B Greer; Alexander Schneider; Dhiraj Yadav; Tooru Shimosegawa Journal: Pancreatology Date: 2016-02-16 Impact factor: 3.996
Authors: Philippe Lévy; Marc Barthet; Bruno Richard Mollard; Michel Amouretti; Anne-Marie Marion-Audibert; François Dyard Journal: Gastroenterol Clin Biol Date: 2006 Jun-Jul
Authors: Jorge D Machicado; Stephen T Amann; Michelle A Anderson; Judah Abberbock; Stuart Sherman; Darwin L Conwell; Gregory A Cote; Vikesh K Singh; Michele D Lewis; Samer Alkaade; Bimaljit S Sandhu; Nalini M Guda; Thiruvengadam Muniraj; Gong Tang; John Baillie; Randall E Brand; Timothy B Gardner; Andres Gelrud; Christopher E Forsmark; Peter A Banks; Adam Slivka; C Mel Wilcox; David C Whitcomb; Dhiraj Yadav Journal: Am J Gastroenterol Date: 2017-02-28 Impact factor: 10.864
Authors: Stephen T Amann; Dhiraj Yadav; M Micheal Barmada; Michael O'Connell; Elizabeth D Kennard; Michelle Anderson; John Baillie; Stuart Sherman; Joseph Romagnuolo; Robert H Hawes; Samer Alkaade; Randall E Brand; Michele D Lewis; Timothy B Gardner; Andres Gelrud; Mary E Money; Peter A Banks; Adam Slivka; David C Whitcomb Journal: Pancreas Date: 2013-03 Impact factor: 3.327