Luis F Lara1, Solvejg Wastvedt2, James S Hodges2, Piotr Witkowski3, Martin Wijkstrom4, R Matthew Walsh5, Vikesh K Singh6, Sarah J Schwarzenberg7, Timothy L Pruett8, Andrew Posselt9, Bashoo Naziruddin10, Jaimie D Nathan, Katherine A Morgan11, Rebecca Mitchell2, Varvara A Kirchner8, SriPrakash L Mokshagundam12, Betul Hatipoglu13, Timothy B Gardner14, Martin L Freeman15, Srinath Chinnakotla8, Gregory J Beilman8, Maisam Abu-El-Haija, Darwin L Conwell1, Melena D Bellin16. 1. From the Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH. 2. School of Public Health, University of Minnesota, Minneapolis, MN. 3. Department of Surgery, University of Chicago, Chicago, IL. 4. Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. 5. Department of General Surgery, Cleveland Clinic, Cleveland, OH. 6. Division of Gastroenterology, Department of Medicine, John Hopkins Medical Institutions, Baltimore, MD. 7. Department of Pediatrics. 8. Department of Surgery, University of Minnesota Medical School, Minneapolis, MN. 9. Department of Surgery, University of California San Francisco, San Francisco, CA. 10. Department of Surgery, Islet Cell Processing Laboratory, Baylor Health, Dallas, TX. 11. Division of GI and Laparoscopic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC. 12. Department of Medicine, University of Louisville, Louisville, KY. 13. Department of Medicine, Division of Clinical and Molecular Endocrinology, University Hospitals, Cleveland, OH. 14. Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH. 15. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN. 16. Division of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.
Abstract
OBJECTIVES: Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. METHODS: We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. RESULTS: Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). CONCLUSIONS: Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.
OBJECTIVES: Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. METHODS: We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes. RESULTS: Of 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005). CONCLUSIONS: Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.
Authors: Y van der Steen; I Myin-Germeys; M van Nierop; M Ten Have; R de Graaf; S van Dorsselaer; J van Os; R van Winkel Journal: Epidemiol Psychiatr Sci Date: 2018-04-16 Impact factor: 6.892
Authors: Jorge D Machicado; Stephen T Amann; Michelle A Anderson; Judah Abberbock; Stuart Sherman; Darwin L Conwell; Gregory A Cote; Vikesh K Singh; Michele D Lewis; Samer Alkaade; Bimaljit S Sandhu; Nalini M Guda; Thiruvengadam Muniraj; Gong Tang; John Baillie; Randall E Brand; Timothy B Gardner; Andres Gelrud; Christopher E Forsmark; Peter A Banks; Adam Slivka; C Mel Wilcox; David C Whitcomb; Dhiraj Yadav Journal: Am J Gastroenterol Date: 2017-02-28 Impact factor: 10.864
Authors: Melena D Bellin; Tossapol Kerdsirichairat; Gregory J Beilman; Ty B Dunn; Srinath Chinnakotla; Timothy L Pruett; David R Radosevich; Sarah J Schwarzenberg; David E R Sutherland; Mustafa A Arain; Martin L Freeman Journal: Clin Gastroenterol Hepatol Date: 2016-03-08 Impact factor: 11.382
Authors: Oye Gureje; Michael Von Korff; Lola Kola; Koen Demyttenaere; Yanling He; José Posada-Villa; Jean Pierre Lepine; Matthias C Angermeyer; Daphna Levinson; Giovanni de Girolamo; Noboru Iwata; Aimee Karam; Guilherme Luiz Guimaraes Borges; Ron de Graaf; Mark Oakley Browne; Dan J Stein; Josep Maria Haro; Evelyn J Bromet; Ron C Kessler; Jordi Alonso Journal: Pain Date: 2007-06-13 Impact factor: 6.961
Authors: Srinath Chinnakotla; Gregory J Beilman; Ty B Dunn; Melena D Bellin; Martin L Freeman; David M Radosevich; Mustafa Arain; Stuart K Amateau; J Shawn Mallery; Sarah J Schwarzenberg; Alfred Clavel; Joshua Wilhelm; R Paul Robertson; Louise Berry; Marie Cook; Bernhard J Hering; David E R Sutherland; Timothy L Pruett Journal: Ann Surg Date: 2015-10 Impact factor: 12.969
Authors: J Solomina; J Gołębiewska; M R Kijek; A Kotukhov; P J Bachul; L Basto; K Gołąb; E Konsur; K Cieply; N Fillman; L-J Wang; C C Thomas; L H Philipson; M Tibudan; A Dębska-Ślizień; J Fung; A Gelrud; J B Matthews; P Witkowski Journal: Transplant Proc Date: 2017-12 Impact factor: 1.066