Michele Dileone1, Laura Mordillo-Mateos2, Antonio Oliviero3, Guglielmo Foffani4. 1. CINAC, Hospital Universitario HM Puerta del Sur, Universidad CEU-San Pablo, Móstoles, Madrid, Spain. 2. Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. 3. Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. Electronic address: antonio.oliviero@hotmail.com. 4. CINAC, Hospital Universitario HM Puerta del Sur, Universidad CEU-San Pablo, Móstoles, Madrid, Spain; Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. Electronic address: gfoffani.hmcinac@hmhospitales.com.
Abstract
BACKGROUND: Transcranial static magnetic field stimulation (tSMS) was recently added to the family of inhibitory non-invasive brain stimulation techniques. However, the application of tSMS for 10-20 min over the motor cortex (M1) induces only short-lasting effects that revert within few minutes. OBJECTIVE: We examined whether increasing the duration of tSMS to 30 min leads to long-lasting changes in cortical excitability, which is critical for translating tSMS toward clinical applications. METHODS: The study comprised 5 experiments in 45 healthy subjects. We assessed the impact of 30-min-tSMS over M1 on corticospinal excitability, as measured by the amplitude of motor evoked potentials (MEPs) and resting motor thresholds (RMTs) to single-pulse transcranial magnetic stimulation (TMS) (experiments 1-2). We then assessed the impact of 30-min-tSMS on intracortical excitability, as measured by short-interval intracortical facilitation (SICF) and short-interval intracortical inhibition (SICI) using paired-pulse TMS protocols (experiments 2-4). We finally assessed the impact of 10-min-tSMS on SICF and SICI (experiment 5). RESULTS: 30-min-tSMS decreased MEP amplitude compared to sham for at least 30 min after the end of the stimulation. This long-lasting effect was associated with increased SICF and reduced SICI. 10-min-tSMS -previously reported to induce a short-lasting decrease in MEP amplitude- produced the opposite changes in intracortical excitability, decreasing SICF while increasing SICI. CONCLUSIONS: These results suggest a dissociation of intracortical changes in the consolidation from short-lasting to long-lasting decrease of corticospinal excitability induced by tSMS. The long-lasting effects of 30-min-tSMS open the way to the translation of this simple, portable and low-cost technique toward clinical trials.
BACKGROUND: Transcranial static magnetic field stimulation (tSMS) was recently added to the family of inhibitory non-invasive brain stimulation techniques. However, the application of tSMS for 10-20 min over the motor cortex (M1) induces only short-lasting effects that revert within few minutes. OBJECTIVE: We examined whether increasing the duration of tSMS to 30 min leads to long-lasting changes in cortical excitability, which is critical for translating tSMS toward clinical applications. METHODS: The study comprised 5 experiments in 45 healthy subjects. We assessed the impact of 30-min-tSMS over M1 on corticospinal excitability, as measured by the amplitude of motor evoked potentials (MEPs) and resting motor thresholds (RMTs) to single-pulse transcranial magnetic stimulation (TMS) (experiments 1-2). We then assessed the impact of 30-min-tSMS on intracortical excitability, as measured by short-interval intracortical facilitation (SICF) and short-interval intracortical inhibition (SICI) using paired-pulse TMS protocols (experiments 2-4). We finally assessed the impact of 10-min-tSMS on SICF and SICI (experiment 5). RESULTS: 30-min-tSMS decreased MEP amplitude compared to sham for at least 30 min after the end of the stimulation. This long-lasting effect was associated with increased SICF and reduced SICI. 10-min-tSMS -previously reported to induce a short-lasting decrease in MEP amplitude- produced the opposite changes in intracortical excitability, decreasing SICF while increasing SICI. CONCLUSIONS: These results suggest a dissociation of intracortical changes in the consolidation from short-lasting to long-lasting decrease of corticospinal excitability induced by tSMS. The long-lasting effects of 30-min-tSMS open the way to the translation of this simple, portable and low-cost technique toward clinical trials.
Authors: Vanesa Soto-León; Mabel Torres-Llacsa; Laura Mordillo-Mateos; Carmen Carrasco-López; José A Pineda-Pardo; Ana I Velasco; Laura Abad-Toribio; Jesús Tornero; Guglielmo Foffani; Bryan A Strange; Antonio Oliviero Journal: Sci Rep Date: 2022-05-12 Impact factor: 4.996
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Authors: José A Pineda-Pardo; Ignacio Obeso; Pasqualina Guida; Michele Dileone; Bryan A Strange; José A Obeso; Antonio Oliviero; Guglielmo Foffani Journal: Commun Biol Date: 2019-10-31
Authors: Simone Rossi; Andrea Antal; Sven Bestmann; Marom Bikson; Carmen Brewer; Jürgen Brockmöller; Linda L Carpenter; Massimo Cincotta; Robert Chen; Jeff D Daskalakis; Vincenzo Di Lazzaro; Michael D Fox; Mark S George; Donald Gilbert; Vasilios K Kimiskidis; Giacomo Koch; Risto J Ilmoniemi; Jean Pascal Lefaucheur; Letizia Leocani; Sarah H Lisanby; Carlo Miniussi; Frank Padberg; Alvaro Pascual-Leone; Walter Paulus; Angel V Peterchev; Angelo Quartarone; Alexander Rotenberg; John Rothwell; Paolo M Rossini; Emiliano Santarnecchi; Mouhsin M Shafi; Hartwig R Siebner; Yoshikatzu Ugawa; Eric M Wassermann; Abraham Zangen; Ulf Ziemann; Mark Hallett Journal: Clin Neurophysiol Date: 2020-10-24 Impact factor: 4.861