Literature DB >> 29484327

The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.

Wen Zhou1, Mohammad Almeqdadi2, Michael E Xifaras2, Imogen A Riddell3, Ömer H Yilmaz2, Stephen J Lippard3.   

Abstract

A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

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Year:  2018        PMID： 29484327      PMCID： PMC5988251          DOI： 10.1039/c8cc00393a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

1.  Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

Authors:  E R Jamieson; S J Lippard
Journal:  Chem Rev       Date:  1999-09-08       Impact factor: 60.622

2.  Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile.

Authors:  Ga Young Park; Justin J Wilson; Ying Song; Stephen J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-06       Impact factor: 11.205

3.  X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.

Authors:  Dong Wang; Guangyu Zhu; Xuhui Huang; Stephen J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-06       Impact factor: 11.205

4.  High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Authors:  Hui Gao; Joshua M Korn; Stéphane Ferretti; John E Monahan; Youzhen Wang; Mallika Singh; Chao Zhang; Christian Schnell; Guizhi Yang; Yun Zhang; O Alejandro Balbin; Stéphanie Barbe; Hongbo Cai; Fergal Casey; Susmita Chatterjee; Derek Y Chiang; Shannon Chuai; Shawn M Cogan; Scott D Collins; Ernesta Dammassa; Nicolas Ebel; Millicent Embry; John Green; Audrey Kauffmann; Colleen Kowal; Rebecca J Leary; Joseph Lehar; Ying Liang; Alice Loo; Edward Lorenzana; E Robert McDonald; Margaret E McLaughlin; Jason Merkin; Ronald Meyer; Tara L Naylor; Montesa Patawaran; Anupama Reddy; Claudia Röelli; David A Ruddy; Fernando Salangsang; Francesca Santacroce; Angad P Singh; Yan Tang; Walter Tinetto; Sonja Tobler; Roberto Velazquez; Kavitha Venkatesan; Fabian Von Arx; Hui Qin Wang; Zongyao Wang; Marion Wiesmann; Daniel Wyss; Fiona Xu; Hans Bitter; Peter Atadja; Emma Lees; Francesco Hofmann; En Li; Nicholas Keen; Robert Cozens; Michael Rugaard Jensen; Nancy K Pryer; Juliet A Williams; William R Sellers
Journal:  Nat Med       Date:  2015-10-19       Impact factor: 53.440

Review 5.  Organoids as an in vitro model of human development and disease.

Authors:  Aliya Fatehullah; Si Hui Tan; Nick Barker
Journal:  Nat Cell Biol       Date:  2016-03       Impact factor: 28.824

6.  Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes.

Authors:  Imogen A Riddell; Keli Agama; Ga Young Park; Yves Pommier; Stephen J Lippard
Journal:  ACS Chem Biol       Date:  2016-10-06       Impact factor: 5.100

7.  cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.

Authors:  Katherine S Lovejoy; Ryan C Todd; Shuzhong Zhang; Michael S McCormick; J Alejandro D'Aquino; Joyce T Reardon; Aziz Sancar; Kathleen M Giacomini; Stephen J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-25       Impact factor: 11.205

Review 8.  Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.

Authors:  G Chu
Journal:  J Biol Chem       Date:  1994-01-14       Impact factor: 5.157

9.  Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis.

Authors:  Matthew W Kellinger; Ga Young Park; Jenny Chong; Stephen J Lippard; Dong Wang
Journal:  J Am Chem Soc       Date:  2013-08-25       Impact factor: 15.419

10.  Pt(IV) prodrugs designed to bind non-covalently to human serum albumin for drug delivery.

Authors:  Yao-Rong Zheng; Kogularamanan Suntharalingam; Timothy C Johnstone; Hyunsuk Yoo; Wei Lin; Jamar G Brooks; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2014-06-06       Impact factor: 15.419
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  4 in total

1.  DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin.

Authors:  Ali A Almaqwashi; Wen Zhou; M Nabuan Naufer; Imogen A Riddell; Ömer H Yilmaz; Stephen J Lippard; Mark C Williams
Journal:  J Am Chem Soc       Date:  2019-01-17       Impact factor: 15.419

2.  Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.

Authors:  Đenana Miodragović; Antonello Merlino; Elden P Swindell; Abraham Bogachkov; Richard W Ahn; Sara Abuhadba; Giarita Ferraro; Tiziano Marzo; Andrew P Mazar; Luigi Messori; Thomas V O'Halloran
Journal:  J Am Chem Soc       Date:  2019-04-15       Impact factor: 16.383

Review 3.  Monofunctional Platinum(II) Anticancer Agents.

Authors:  Suxing Jin; Yan Guo; Zijian Guo; Xiaoyong Wang
Journal:  Pharmaceuticals (Basel)       Date:  2021-02-07

4.  A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells.

Authors:  Maiara de S Oliveira; Marília I F Barbosa; Thiago Belarmino de Souza; Diogo R M Moreira; Felipe Terra Martins; Wilmer Villarreal; Rafael P Machado; Antônio Carlos Doriguetto; Milena B P Soares; Daniel P Bezerra
Journal:  Redox Biol       Date:  2018-10-12       Impact factor: 11.799
  4 in total

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