| Literature DB >> 29483683 |
Jin-Soo Kim1,2.
Abstract
Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR-Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.Entities:
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Year: 2018 PMID: 29483683 DOI: 10.1038/s41477-018-0115-z
Source DB: PubMed Journal: Nat Plants ISSN: 2055-0278 Impact factor: 15.793