Literature DB >> 29479127

A Horizontal Multi-Purpose Microbeam System.

Y Xu1, G Randers-Pehrson2, S A Marino2, G Garty2, A Harken2, D J Brenner2.   

Abstract

A horizontal multi-purpose microbeam system with a single electrostatic quadruplet focusing lens has been developed at the Columbia University Radiological Research Accelerator Facility (RARAF). It is coupled with the RARAF 5.5 MV Singleton accelerator (High Voltage Engineering Europa, the Netherlands) and provides micrometer-size beam for single cell irradiation experiments. It is also used as the primary beam for a neutron microbeam and microPIXE (particle induced x-ray emission) experiment because of its high particle fluence. The optimization of this microbeam has been investigated with ray tracing simulations and the beam spot size has been verified by different measurements.

Entities:  

Year:  2018        PMID： 29479127      PMCID： PMC5821436          DOI： 10.1016/j.nima.2018.01.062

Source DB:  PubMed          Journal:  Nucl Instrum Methods Phys Res A        ISSN： 0168-9002            Impact factor:   1.455


  6 in total

1.  Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells.

Authors:  Hongning Zhou; Gerhard Randers-Pehrson; Charles R Geard; David J Brenner; Eric J Hall; Tom K Hei
Journal:  Radiat Res       Date:  2003-11       Impact factor: 2.841

2.  Microbeams: a potent mix of physics and biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation Response.

Authors:  D J Brenner; E J Hall
Journal:  Radiat Prot Dosimetry       Date:  2002       Impact factor: 0.972

3.  An accelerator-based neutron microbeam system for studies of radiation effects.

Authors:  Yanping Xu; Gerhard Randers-Pehrson; Stephen A Marino; Alan W Bigelow; Mark S Akselrod; Jeff G Sykora; David J Brenner
Journal:  Radiat Prot Dosimetry       Date:  2010-12-03       Impact factor: 0.972

4.  Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway.

Authors:  Hongning Zhou; Vladimir N Ivanov; Joseph Gillespie; Charles R Geard; Sally A Amundson; David J Brenner; Zengliang Yu; Howard B Lieberman; Tom K Hei
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-03       Impact factor: 11.205

5.  Metabolic oxygen consumption measurement with a single-cell biosensor after particle microbeam irradiation.

Authors:  Yanping Xu; Bo Zhang; Mark Messerli; Gerhard Randers-Pehrson; Tom K Hei; David J Brenner
Journal:  Radiat Environ Biophys       Date:  2014-10-22       Impact factor: 1.925

6.  The Columbia University Sub-micron Charged Particle Beam.

Authors:  Gerhard Randers-Pehrson; Gary W Johnson; Stephen A Marino; Yanping Xu; Alexander D Dymnikov; David J Brenner
Journal:  Nucl Instrum Methods Phys Res A       Date:  2009-10-11       Impact factor: 1.455
  6 in total

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