Alyse Bedell1, Tiffany Taft2, Meredith R Craven2, Livia Guadagnoli2, Ikuo Hirano2, Nirmala Gonsalves2. 1. Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St. #1400, Chicago, IL, 60611, USA. alyse.bedell@northwestern.edu. 2. Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St. #1400, Chicago, IL, 60611, USA.
Abstract
BACKGROUND: Eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE) are chronic immune-mediated conditions of the digestive tract, which affect the stomach only, or the stomach and small intestines, respectively. Though these disorders are uncommon, they are being increasingly recognized and diagnosed. While health-related quality of life (HRQOL) has been evaluated in other eosinophilic gastrointestinal diseases, this study is the first to describe HRQOL impacts unique to EG/EGE. AIMS: This study aims to qualitatively describe experiences of adults diagnosed with EG and EGE. We aim to identify impacts on HRQOL in this population in order to inform clinical care and assessment. METHODS: Seven patients diagnosed with EG or EGE participated in semi-structured interviews assessing common domains of HRQOL. RESULTS: Four distinct themes emerged from qualitative analyses, which represent impacts to HRQOL: the psychological impact of the diagnosis, impact on social relationships, financial impact, and impact on the body. These generally improved over time and with effective treatment. CONCLUSIONS: This study demonstrated that patients with EG/EGE experience impacts to HRQOL, some of which differ from HRQOL of other eosinophilic gastrointestinal diseases. These results support the development of a disease-specific measure, or adaptation of an existing measure, to assess HRQOL in EG/EGE.
BACKGROUND:Eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE) are chronic immune-mediated conditions of the digestive tract, which affect the stomach only, or the stomach and small intestines, respectively. Though these disorders are uncommon, they are being increasingly recognized and diagnosed. While health-related quality of life (HRQOL) has been evaluated in other eosinophilic gastrointestinal diseases, this study is the first to describe HRQOL impacts unique to EG/EGE. AIMS: This study aims to qualitatively describe experiences of adults diagnosed with EG and EGE. We aim to identify impacts on HRQOL in this population in order to inform clinical care and assessment. METHODS: Seven patients diagnosed with EG or EGE participated in semi-structured interviews assessing common domains of HRQOL. RESULTS: Four distinct themes emerged from qualitative analyses, which represent impacts to HRQOL: the psychological impact of the diagnosis, impact on social relationships, financial impact, and impact on the body. These generally improved over time and with effective treatment. CONCLUSIONS: This study demonstrated that patients with EG/EGE experience impacts to HRQOL, some of which differ from HRQOL of other eosinophilic gastrointestinal diseases. These results support the development of a disease-specific measure, or adaptation of an existing measure, to assess HRQOL in EG/EGE.
Authors: Daniel A Leffler; Sarah Acaster; Katy Gallop; Melinda Dennis; Ciarán P Kelly; Daniel C Adelman Journal: Value Health Date: 2017-02-14 Impact factor: 5.725
Authors: S D Dorn; L Hernandez; M T Minaya; C B Morris; Y Hu; J Leserman; S Lewis; A Lee; S I Bangdiwala; P H R Green; D A Drossman Journal: Aliment Pharmacol Ther Date: 2009-12-15 Impact factor: 8.171
Authors: Sophie Lebel; Gabriela Jakubovits; Zeev Rosberger; Carmen Loiselle; Carole Seguin; Catherine Cornaz; Jan Ingram; Linda August; Andre Lisbona Journal: J Psychosom Res Date: 2003-11 Impact factor: 3.006
Authors: Tetsuo Shoda; Ting Wen; Julie M Caldwell; Margaret H Collins; John A Besse; Garrett A Osswald; J Pablo Abonia; Nicoleta C Arva; Dan Atkins; Kelley E Capocelli; Evan S Dellon; Gary W Falk; Nirmala Gonsalves; Sandeep K Gupta; Ikuo Hirano; Vincent A Mukkada; Philip E Putnam; Rachel M Sheridan; Amanda K Rudman Spergel; Jonathan M Spergel; Joshua B Wechsler; Guang-Yu Yang; Seema S Aceves; Glenn T Furuta; Marc E Rothenberg Journal: J Allergy Clin Immunol Date: 2019-11-16 Impact factor: 10.793
Authors: Evan S Dellon; Kathryn A Peterson; Joseph A Murray; Gary W Falk; Nirmala Gonsalves; Mirna Chehade; Robert M Genta; John Leung; Paneez Khoury; Amy D Klion; Sabine Hazan; Michael Vaezi; Adam C Bledsoe; Sandy R Durrani; Chao Wang; Camilla Shaw; Alan T Chang; Bhupinder Singh; Amol P Kamboj; Henrik S Rasmussen; Marc E Rothenberg; Ikuo Hirano Journal: N Engl J Med Date: 2020-10-22 Impact factor: 91.245
Authors: Evan S Dellon; Nirmala Gonsalves; Marc E Rothenberg; Ikuo Hirano; Mirna Chehade; Kathryn A Peterson; Gary W Falk; Joseph A Murray; Lauren T Gehman; Alan T Chang; Bhupinder Singh; Henrik S Rasmussen; Robert M Genta Journal: Clin Gastroenterol Hepatol Date: 2021-06-02 Impact factor: 11.382
Authors: Marc E Rothenberg; Shawna K B Hottinger; Nirmala Gonsalves; Glenn T Furuta; Margaret H Collins; Nicholas J Talley; Kathryn Peterson; Calies Menard-Katcher; Macie Smith; Ikuo Hirano; Robert M Genta; Mirna Chehade; Sandeep K Gupta; Jonathan M Spergel; Seema S Aceves; Evan S Dellon Journal: J Allergy Clin Immunol Date: 2021-12-22 Impact factor: 10.793