Katharina J Penczynski1,2, Christian Herder3,4, Danika Krupp1, Johanna Rienks5, Sarah Egert6, Stefan A Wudy7, Michael Roden3,4,8, Thomas Remer1, Anette E Buyken9,10. 1. DONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Heinstück 11, 44225, Dortmund, Germany. 2. Institute of Nutrition, Consumption and Health, Faculty of Natural Sciences, University of Paderborn, Warburger Straße 100, 33098, Paderborn, Germany. 3. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany. 4. German Center for Diabetes Research, Ingolstädter Landstraße 1, 85764, München-Neuherberg, Germany. 5. Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Endenicher Allee 11-13, 53115, Bonn, Germany. 6. Department of Nutrition and Food Sciences (IEL), Nutritional Physiology, University of Bonn, Nußallee 9, 53115, Bonn, Germany. 7. Pediatric Endocrinology and Diabetology, Laboratory for Translational Hormone Analytics, Peptide Hormone Research Unit, Center of Child and Adolescent Medicine, Justus Liebig University, Feulgenstrasse 12, 35392, Gießen, Germany. 8. Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany. 9. DONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Heinstück 11, 44225, Dortmund, Germany. anette.buyken@uni-paderborn.de. 10. Institute of Nutrition, Consumption and Health, Faculty of Natural Sciences, University of Paderborn, Warburger Straße 100, 33098, Paderborn, Germany. anette.buyken@uni-paderborn.de.
Abstract
PURPOSE: Flavonoid consumption during adolescence could contribute to preventing adult onset of type 2 diabetes mellitus. We investigated the prospective association between habitual intake of flavonoids from fruit and vegetables (FlavFV) during adolescence and risk markers of type 2 diabetes in early adulthood. METHODS: This analysis included participants of the DONALD Study, who had provided a fasting blood sample in adulthood (18-39 years), data on FlavFV-intake during adolescence (females: 9-15 years, males: 10-16 years) and relevant covariates. Habitual FlavFV-intake was either estimated using repeated 3-day weighed dietary records (n = 268), or the validated biomarker hippuric acid (uHA)-excretion in repeated 24-h urine samples (n = 241). Multivariable linear regressions were performed to analyse the prospective associations of FlavFV or uHA with homeostasis model assessment insulin sensitivity (HOMA2-%S), hepatic steatosis index (HSI), fatty liver index (FLI) and a pro-inflammatory score. RESULTS: Higher FlavFV-intake was independently related to higher HOMA2-%S among females (Ptrend = 0.03), but not among males. Both FlavFV-intake and uHA-excretion were inversely associated with HSI (Ptrend < 0.0001 and Ptrend = 0.02, respectively) and the pro-inflammatory score (Ptrend = 0.02 and Ptrend = 0.008, respectively), but not with FLI. CONCLUSIONS: Our data indicate that flavonoid consumption from fruit and vegetables during adolescence is associated with a favourable risk factor profile for type 2 diabetes in early adulthood.
PURPOSE:Flavonoid consumption during adolescence could contribute to preventing adult onset of type 2 diabetes mellitus. We investigated the prospective association between habitual intake of flavonoids from fruit and vegetables (FlavFV) during adolescence and risk markers of type 2 diabetes in early adulthood. METHODS: This analysis included participants of the DONALD Study, who had provided a fasting blood sample in adulthood (18-39 years), data on FlavFV-intake during adolescence (females: 9-15 years, males: 10-16 years) and relevant covariates. Habitual FlavFV-intake was either estimated using repeated 3-day weighed dietary records (n = 268), or the validated biomarker hippuric acid (uHA)-excretion in repeated 24-h urine samples (n = 241). Multivariable linear regressions were performed to analyse the prospective associations of FlavFV or uHA with homeostasis model assessment insulin sensitivity (HOMA2-%S), hepatic steatosis index (HSI), fatty liver index (FLI) and a pro-inflammatory score. RESULTS: Higher FlavFV-intake was independently related to higher HOMA2-%S among females (Ptrend = 0.03), but not among males. Both FlavFV-intake and uHA-excretion were inversely associated with HSI (Ptrend < 0.0001 and Ptrend = 0.02, respectively) and the pro-inflammatory score (Ptrend = 0.02 and Ptrend = 0.008, respectively), but not with FLI. CONCLUSIONS: Our data indicate that flavonoid consumption from fruit and vegetables during adolescence is associated with a favourable risk factor profile for type 2 diabetes in early adulthood.
Entities:
Keywords:
24-Hour urinary hippuric acid excretion; Chronic subclinical inflammation; Flavonoids from fruit and vegetables; Homeostasis model assessment of insulin sensitivity; Indices of hepatic steatosis; Prospective
Authors: Katharina J Penczynski; Thomas Remer; Christian Herder; Hermann Kalhoff; Johanna Rienks; Daniel F Markgraf; Michael Roden; Anette E Buyken Journal: Nutrients Date: 2018-04-14 Impact factor: 5.717