| Literature DB >> 29464434 |
V V Boiko1, V R Romanyuk2, O P Gnatyuk3, O O Ilchenko4, S O Karakhim5, A V Korovin2, G I Dovbeshko3.
Abstract
The impact of confinement of DNA molecules in a limited volume of the cavity of photonic crystals (PC) on the vibrational properties of the DNA molecule and its conformation is studied. According to our preliminary study, the aqueous shell is removed when the DNA molecules are infiltrated into the PC cavities. Raman scattering (RS) DNA marker lines showed a dramatic conformational change of DNA in the PC cavities and the appearance of new unknown conformational states. We observed the enhancement of vibrational modes of DNA in the PC in comparison with free DNA of about tenfold and the absence of vibrational modes in DNA bases in a region of 1450-1700 cm-1. The observed features in the RS spectra of DNA are explained by the impact of confined interglobular volume and strong localization of the electromagnetic field. Namely, FDTD simulations in linear regime demonstrate the localization of light in cavities of PC with an approximately ninefold enhancement of the electric field within the photonic stop-band, which is the main reason for RS amplification.Keywords: Confined volume; DNA; DNA conformation; FDTD simulations; Photonic crystal; Raman spectra; Vibrational modes
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Year: 2018 PMID： 29464434 PMCID： PMC5835003 DOI： 10.1007/s10867-018-9480-0
Source DB: PubMed Journal: J Biol Phys ISSN： 0092-0606 Impact factor: 1.365