Literature DB >> 29463682

Metabolism in pluripotency: Both driver and passenger?

Perrine Dahan1, Vivian Lu2, Robert M T Nguyen1, Stephanie A L Kennedy1,3, Michael A Teitell4,5,6,7,8,9.   

Abstract

Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic demands to power rapid division. For many years considered a passive component or "passenger" of cell-fate determination, cell metabolism is now starting to take center stage as a driver of cell fate outcomes. This review provides an update and analysis of our current understanding of PSC metabolism and its role in self-renewal, differentiation, and somatic cell reprogramming to pluripotency. Moreover, we present evidence on the active roles metabolism plays in shaping the epigenome to influence patterns of gene expression that may model key features of early embryonic development.
© 2019 by The American Society for Biochemistry and Molecular Biology, Inc.

Keywords:  cell fate; differentiation; epigenetics; metabolism; mitochondria; pluripotency; reprogramming; stem cells

Mesh：

Year:  2018        PMID： 29463682      PMCID： PMC6462533          DOI： 10.1074/jbc.TM117.000832

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  98 in total

1.  A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity.

Authors:  Rosa M Marión; Katerina Strati; Han Li; Matilde Murga; Raquel Blanco; Sagrario Ortega; Oscar Fernandez-Capetillo; Manuel Serrano; Maria A Blasco
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

2.  Derivation of novel human ground state naive pluripotent stem cells.

Authors:  Ohad Gafni; Leehee Weinberger; Abed AlFatah Mansour; Yair S Manor; Elad Chomsky; Dalit Ben-Yosef; Yael Kalma; Sergey Viukov; Itay Maza; Asaf Zviran; Yoach Rais; Zohar Shipony; Zohar Mukamel; Vladislav Krupalnik; Mirie Zerbib; Shay Geula; Inbal Caspi; Dan Schneir; Tamar Shwartz; Shlomit Gilad; Daniela Amann-Zalcenstein; Sima Benjamin; Ido Amit; Amos Tanay; Rada Massarwa; Noa Novershtern; Jacob H Hanna
Journal:  Nature       Date:  2013-10-30       Impact factor: 49.962

3.  Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency.

Authors:  Hyunsoo Kim; Hyonchol Jang; Tae Wan Kim; Byung-Hee Kang; Sang Eun Lee; Yoon Kyung Jeon; Doo Hyun Chung; Jinmi Choi; Jihoon Shin; Eun-Jung Cho; Hong-Duk Youn
Journal:  Stem Cells       Date:  2015-06-23       Impact factor: 6.277

4.  O-GlcNAc is required for the survival of primed pluripotent stem cells and their reversion to the naïve state.

Authors:  Taichi Miura; Shoko Nishihara
Journal:  Biochem Biophys Res Commun       Date:  2016-10-27       Impact factor: 3.575

5.  Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions.

Authors:  Hui Zhang; Mehmet G Badur; Ajit S Divakaruni; Seth J Parker; Christian Jäger; Karsten Hiller; Anne N Murphy; Christian M Metallo
Journal:  Cell Rep       Date:  2016-07-28       Impact factor: 9.423

6.  Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

Authors:  Timothy Alexander Hore; Ferdinand von Meyenn; Mirunalini Ravichandran; Martin Bachman; Gabriella Ficz; David Oxley; Fátima Santos; Shankar Balasubramanian; Tomasz P Jurkowski; Wolf Reik
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-11       Impact factor: 11.205

7.  Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits.

Authors:  B Fischer; B D Bavister
Journal:  J Reprod Fertil       Date:  1993-11

8.  Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells.

Authors:  Stefan M Schieke; Mingchao Ma; Liu Cao; J Philip McCoy; Chengyu Liu; Nancy F Hensel; A John Barrett; Manfred Boehm; Toren Finkel
Journal:  J Biol Chem       Date:  2008-08-18       Impact factor: 5.157

9.  Derivation of naive human embryonic stem cells.

Authors:  Carol B Ware; Angelique M Nelson; Brigham Mecham; Jennifer Hesson; Wenyu Zhou; Erica C Jonlin; Antonio J Jimenez-Caliani; Xinxian Deng; Christopher Cavanaugh; Savannah Cook; Paul J Tesar; Jeffrey Okada; Lilyana Margaretha; Henrik Sperber; Michael Choi; C Anthony Blau; Piper M Treuting; R David Hawkins; Vincenzo Cirulli; Hannele Ruohola-Baker
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-12       Impact factor: 11.205

10.  NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.

Authors:  Kate E Hawkins; Shona Joy; Juliette M K M Delhove; Vassilios N Kotiadis; Emilio Fernandez; Lorna M Fitzpatrick; James R Whiteford; Peter J King; Juan P Bolanos; Michael R Duchen; Simon N Waddington; Tristan R McKay
Journal:  Cell Rep       Date:  2016-02-18       Impact factor: 9.423
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  19 in total

1.  An Air Bubble-Isolating Rotating Wall Vessel Bioreactor for Improved Spheroid/Organoid Formation.

Authors:  Michael A Phelan; Anthony L Gianforcaro; Jonathan A Gerstenhaber; Peter I Lelkes
Journal:  Tissue Eng Part C Methods       Date:  2019-08       Impact factor: 3.056

2.  Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.

Authors:  Yi Wu; Keshi Chen; Linpeng Li; Zhihong Hao; Tianyu Wang; Yang Liu; Guangsuo Xing; Zichao Liu; Heying Li; Hao Yuan; Jianghuan Lu; Cheng Zhang; Jinye Zhang; Danyun Zhao; Junwei Wang; Jinfu Nie; Dan Ye; Guangjin Pan; Wai-Yee Chan; Xingguo Liu
Journal:  Cell Death Differ       Date:  2022-05-25       Impact factor: 15.828

Review 3.  Regulation of energy metabolism in human pluripotent stem cells.

Authors:  Weiwei Liu; Guokai Chen
Journal:  Cell Mol Life Sci       Date:  2021-11-13       Impact factor: 9.261

4.  OCT4, SOX2 and NANOG co-regulate glycolysis and participate in somatic induced reprogramming.

Authors:  Ying Ding; Xia Yuan; Yichen Zou; Jiachen Gao; Xianshuai Xu; Hongyan Sun; Qisheng Zuo; Yani Zhang; Bichun Li
Journal:  Cytotechnology       Date:  2022-03-17       Impact factor: 2.040

5.  Multiomics analysis of the NAD+-PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells.

Authors:  Aarin Jones; W Lee Kraus
Journal:  Genes Dev       Date:  2022-06-02       Impact factor: 12.890

6.  Krebs and an alternative TCA cycle!

Authors:  Mary T Doan; Michael A Teitell
Journal:  Cell Res       Date:  2022-06       Impact factor: 46.297

Review 7.  Calcium regulation of stem cells.

Authors:  Hans-Willem Snoeck
Journal:  EMBO Rep       Date:  2020-05-17       Impact factor: 8.807

Review 8.  Metabolo-epigenetics: the interplay of metabolism and epigenetics during early germ cells development

Authors:  Roxane Verdikt; Patrick Allard
Journal:  Biol Reprod       Date:  2021-09-14       Impact factor: 4.161

Review 9.  Mitochondrial DNA Dynamics in Reprogramming to Pluripotency.

Authors:  Alexander J Sercel; Natasha M Carlson; Alexander N Patananan; Michael A Teitell
Journal:  Trends Cell Biol       Date:  2021-04       Impact factor: 21.167

Review 10.  From single cells to tissue self-organization.

Authors:  Aline Xavier da Silveira Dos Santos; Prisca Liberali
Journal:  FEBS J       Date:  2018-11-19       Impact factor: 5.542
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