Literature DB >> 29463536

Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital.

Bin Huang1, Yuting He1, Xingyan Ma1, Renxin Cai2,3, Jianming Zeng2,3, Yang Lu2,3, Weizheng Zhang2,3, Kai Lan2,3, Sunmei E2,3, Yi-Wei Tang4, Barry N Kreiswirth5, Cha Chen6,3, Liang Chen7.   

Abstract

Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  colistin; gene expression; genomics; plasmids; promoter

Mesh：

Substances：

Year:  2018        PMID： 29463536      PMCID： PMC5923141          DOI： 10.1128/AAC.00018-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Multilocus sequence typing of total-genome-sequenced bacteria.

Authors:  Mette V Larsen; Salvatore Cosentino; Simon Rasmussen; Carsten Friis; Henrik Hasman; Rasmus Lykke Marvig; Lars Jelsbak; Thomas Sicheritz-Pontén; David W Ussery; Frank M Aarestrup; Ole Lund
Journal:  J Clin Microbiol       Date:  2012-01-11       Impact factor: 5.948

Review 2.  Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.

Authors:  Laurent Poirel; Aurélie Jayol; Patrice Nordmann
Journal:  Clin Microbiol Rev       Date:  2017-04       Impact factor: 26.132

3.  Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.

Authors:  Laurent Poirel; Nicolas Kieffer; Adrian Brink; Jennifer Coetze; Aurélie Jayol; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

4.  Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City.

Authors:  Brandon Eilertson; Liang Chen; Kalyan D Chavda; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

Review 5.  Transferable resistance to colistin: a new but old threat.

Authors:  Stefan Schwarz; Alan P Johnson
Journal:  J Antimicrob Chemother       Date:  2016-06-24       Impact factor: 5.790

6.  Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae.

Authors:  Aiqing Li; Yong Yang; Minhui Miao; Kalyan D Chavda; José R Mediavilla; Xiaofang Xie; Ping Feng; Yi-Wei Tang; Barry N Kreiswirth; Liang Chen; Hong Du
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

7.  Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

Authors:  Yi-Yun Liu; Yang Wang; Timothy R Walsh; Ling-Xian Yi; Rong Zhang; James Spencer; Yohei Doi; Guobao Tian; Baolei Dong; Xianhui Huang; Lin-Feng Yu; Danxia Gu; Hongwei Ren; Xiaojie Chen; Luchao Lv; Dandan He; Hongwei Zhou; Zisen Liang; Jian-Hua Liu; Jianzhong Shen
Journal:  Lancet Infect Dis       Date:  2015-11-19       Impact factor: 25.071

8.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790

9.  Genetic Analysis of the IncX4 Plasmids: Implications for a Unique Pattern in the mcr-1 Acquisition.

Authors:  Jian Sun; Liang-Xing Fang; Zuowei Wu; Hui Deng; Run-Shi Yang; Xing-Ping Li; Shu-Min Li; Xiao-Ping Liao; Youjun Feng; Ya-Hong Liu
Journal:  Sci Rep       Date:  2017-03-24       Impact factor: 4.379

10.  Complex dissemination of the diversified mcr-1-harbouring plasmids in Escherichia coli of different sequence types.

Authors:  Qingjing Wang; Zhencui Li; Jingxia Lin; Xiuna Wang; Xianbo Deng; Youjun Feng
Journal:  Oncotarget       Date:  2016-12-13
  10 in total
  4 in total

1.  Identification of Novel Mobilized Colistin Resistance Gene mcr-9 in a Multidrug-Resistant, Colistin-Susceptible Salmonella enterica Serotype Typhimurium Isolate.

Authors:  Laura M Carroll; Ahmed Gaballa; Claudia Guldimann; Genevieve Sullivan; Lory O Henderson; Martin Wiedmann
Journal:  mBio       Date:  2019-05-07       Impact factor: 7.867

Review 2.  Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current Reports.

Authors:  Masego Mmatli; Nontombi Marylucy Mbelle; Nontuthuko E Maningi; John Osei Sekyere
Journal:  mSystems       Date:  2020-12-15       Impact factor: 6.496

3.  Clinical Impact of Colistin Banning in Food Animal on mcr-1-Positive Enterobacteriaceae in Patients From Beijing, China, 2009-2019: A Long-Term Longitudinal Observational Study.

Authors:  Qian Zhao; Yiming Li; Yingxin Tian; Yueyun Shen; Shaolin Wang; Ying Zhang
Journal:  Front Microbiol       Date:  2022-02-10       Impact factor: 5.640

4.  Genetic analysis of the first mcr-1 positive Escherichia coli isolate collected from an outpatient in Chile.

Authors:  Camila Gutiérrez; Javier Zenis; Paulette Legarraga; Jaime R Cabrera-Pardo; Patricia García; Helia Bello-Toledo; Andrés Opazo-Capurro; Gerardo González-Rocha
Journal:  Braz J Infect Dis       Date:  2019-06-20       Impact factor: 3.257
  4 in total

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