Literature DB >> 28167551

Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City.

Brandon Eilertson1, Liang Chen2, Kalyan D Chavda2, Barry N Kreiswirth2.   

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and Kmichiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  CRE; KPC; Tn4401b; carbapenems

Mesh：

Substances：

Year:  2017        PMID： 28167551      PMCID： PMC5365676          DOI： 10.1128/AAC.02458-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

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