Mohsen Meidani1,2, Seyed Alireza Mirmohammad Sadeghi3. 1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Department of Infectious Diseases, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
BACKGROUND: Respiratory infections are a frequent cause of fever in neutropenic patients, whereas respiratory viral infections are not frequently considered as a diagnosis, which causes high morbidity and mortality in these patients. MATERIALS AND METHODS: This prospective study was performed on 36 patients with neutropenia who admitted to hospital were eligible for inclusion with fever (single temperature of >38.3°C or a sustained temperature of >38°C for more than 1 h), upper and lower respiratory symptoms. Sampling was performed from the throat of the patient by the sterile swab. All materials were analyzed by quantitative real-time multiplex polymerase chain reaction covering the following viruses; influenza, parainfluenza virus (PIV), rhinovirus (RV), human metapneumovirus, and respiratory syncytial virus (RSV). RESULTS: RV was the most frequently detected virus and then RSV was the most. PIV was not present in any of the tested samples. Furthermore, no substantial differences in the distribution of specific viral species were observed based on age, sex, neutropenia duration, hematological disorder, and respiratory tract symptoms and signs (P > 0.05). CONCLUSION: Our prospective study supports the hypothesis that respiratory viruses play an important role in the development of neutropenic fever, and thus has the potential to individualize infection treatment and to reduce the extensive use of antibiotics in immunocompromised patients with neutropenia.
BACKGROUND: Respiratory infections are a frequent cause of fever in neutropenic patients, whereas respiratory viral infections are not frequently considered as a diagnosis, which causes high morbidity and mortality in these patients. MATERIALS AND METHODS: This prospective study was performed on 36 patients with neutropenia who admitted to hospital were eligible for inclusion with fever (single temperature of >38.3°C or a sustained temperature of >38°C for more than 1 h), upper and lower respiratory symptoms. Sampling was performed from the throat of the patient by the sterile swab. All materials were analyzed by quantitative real-time multiplex polymerase chain reaction covering the following viruses; influenza, parainfluenza virus (PIV), rhinovirus (RV), human metapneumovirus, and respiratory syncytial virus (RSV). RESULTS: RV was the most frequently detected virus and then RSV was the most. PIV was not present in any of the tested samples. Furthermore, no substantial differences in the distribution of specific viral species were observed based on age, sex, neutropenia duration, hematological disorder, and respiratory tract symptoms and signs (P > 0.05). CONCLUSION: Our prospective study supports the hypothesis that respiratory viruses play an important role in the development of neutropenic fever, and thus has the potential to individualize infection treatment and to reduce the extensive use of antibiotics in immunocompromised patients with neutropenia.
Authors: M Camps Serra; C Cervera; T Pumarola; A Moreno; R Perelló; A Torres; M T Jiménez de Anta; M A Marcos Journal: Eur Respir J Date: 2007-10-24 Impact factor: 16.671
Authors: L J R van Elden; A M van Loon; A van der Beek; K A W Hendriksen; A I M Hoepelman; M G J van Kraaij; P Schipper; M Nijhuis Journal: J Clin Microbiol Date: 2003-09 Impact factor: 5.948
Authors: Alma C van de Pol; Anton M van Loon; Tom F W Wolfs; Nicolaas J G Jansen; Monique Nijhuis; Els Klein Breteler; Rob Schuurman; John W A Rossen Journal: J Clin Microbiol Date: 2007-05-16 Impact factor: 5.948
Authors: Leontine J R van Elden; Marian G J van Kraaij; Monique Nijhuis; Karin A W Hendriksen; Ad W Dekker; Maja Rozenberg-Arska; Anton M van Loon Journal: Clin Infect Dis Date: 2001-12-04 Impact factor: 9.079
Authors: Rodrigo Martino; Elena Rámila; Núria Rabella; José Manuel Muñoz; Mercé Peyret; José Manuel Portos; Rosario Laborda; Jorge Sierra Journal: Clin Infect Dis Date: 2002-12-09 Impact factor: 9.079