Literature DB >> 2945429

Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3.

H S Wang, C R Greenberg, J Hewitt, D Kalousek, M R Hayden.   

Abstract

The linked DNA marker for Huntington disease has recently been mapped to the short arm of chromosome 4 by somatic cell hybridization studies. Southern blot analysis of DNA from patients with Wolf-Hirschhorn syndrome (WHS) has suggested that the linked marker maps within the terminal 4p16 band. We have now accomplished subregional assignment of G8 (D4S10) to 4p16.1-16.3 using in situ hybridization techniques on two patients with nonoverlapping interstitial deletions of 4p. The mapping of G8 (D4S10) to a region deleted in patients with WHS will allow the application of new strategies for detecting DNA sequences closer to the locus for Huntington disease.

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Year:  1986        PMID： 2945429      PMCID： PMC1683962     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  4 in total

1.  DNA markers for nervous system diseases.

Authors:  J F Gusella; R E Tanzi; M A Anderson; W Hobbs; K Gibbons; R Raschtchian; T C Gilliam; M R Wallace; N S Wexler; P M Conneally
Journal:  Science       Date:  1984-09-21       Impact factor: 47.728

2.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

3.  Interstitial deletion of the short arm of chromosome 4.

Authors:  M Ray; J Evans; C Rockman-Greenberg; D Wickstrom
Journal:  J Med Genet       Date:  1984-06       Impact factor: 6.318

4.  Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.

Authors:  J F Gusella; R E Tanzi; P I Bader; M C Phelan; R Stevenson; M R Hayden; K J Hofman; A G Faryniarz; K Gibbons
Journal:  Nature       Date:  1985 Nov 7-13       Impact factor: 49.962
  4 in total
  5 in total

Review 1.  Mouse chromosome 11.

Authors:  A M Buchberg; J J Moskow; M S Buckwalter; S A Camper
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

2.  Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

Authors:  B Smith; D Skarecky; U Bengtsson; R E Magenis; N Carpenter; J J Wasmuth
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

3.  Considerations in using linkage analysis as a presymptomatic test for Huntington's disease.

Authors:  L A Farrer; R H Myers; L A Cupples; P M Conneally
Journal:  J Med Genet       Date:  1988-09       Impact factor: 6.318

4.  A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene.

Authors:  M R Hayden; J Hewitt; J J Wasmuth; J J Kastelein; S Langlois; M Conneally; J Haines; B Smith; C Hilbert; D Allard
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

5.  Isolation and characterization of new highly polymorphic DNA markers from the Huntington disease region.

Authors:  B Weber; A Hedrick; S Andrew; O Riess; C Collins; D Kowbel; M R Hayden
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025
  5 in total

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