Literature DB >> 29451305

Treading slowly through hypoxic waters: dichloroacetate to the rescue!

Golam Mezbah Uddin1, Kim L Ho1, Gary D Lopaschuk1.   

Abstract

Entities:  

Keywords:  cardiac metabolism; dichloroacetate; pyruvate dehydrogenase

Mesh：

Substances：

Year:  2018        PMID： 29451305      PMCID： PMC6068224          DOI： 10.1113/JP275898

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  3 in total

1.  An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.

Authors:  G D Lopaschuk; R B Wambolt; R L Barr
Journal:  J Pharmacol Exp Ther       Date:  1993-01       Impact factor: 4.030

2.  Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

Authors:  Michal K Handzlik; Dumitru Constantin-Teodosiu; Paul L Greenhaff; Mark A Cole
Journal:  J Physiol       Date:  2018-03-05       Impact factor: 5.182

3.  Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Authors:  Golam Mezbah Uddin; Neil A Youngson; Bronte M Doyle; David A Sinclair; Margaret J Morris
Journal:  Sci Rep       Date:  2017-11-08       Impact factor: 4.379
  3 in total
  1 in total

1.  The role of dichloroacetate in improving acute hypoxic tolerance and cardiac function: translation to failing hearts?

Authors:  Da Hye Kim; Shelly Chauhan
Journal:  J Physiol       Date:  2018-06-09       Impact factor: 5.182
  1 in total

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