Literature DB >> 29781527

The role of dichloroacetate in improving acute hypoxic tolerance and cardiac function: translation to failing hearts?

Da Hye Kim1,2, Shelly Chauhan1,3.   

Abstract

Entities:  

Keywords:  cardiac hypoxic tolerance; cardiac metabolism; dichloroacetate; myocardial hypoxia; pyruvate dehydrogenase complex

Mesh：

Substances：

Year:  2018        PMID： 29781527      PMCID： PMC6068220          DOI： 10.1113/JP276217

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  5 in total

1.  Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.

Authors:  John R Ussher; Wei Wang; Manoj Gandhi; Wendy Keung; Victor Samokhvalov; Tatsujiro Oka; Cory S Wagg; Jagdip S Jaswal; Robert A Harris; Alexander S Clanachan; Jason R B Dyck; Gary D Lopaschuk
Journal:  Cardiovasc Res       Date:  2012-03-21       Impact factor: 10.787

2.  Treading slowly through hypoxic waters: dichloroacetate to the rescue!

Authors:  Golam Mezbah Uddin; Kim L Ho; Gary D Lopaschuk
Journal:  J Physiol       Date:  2018-03-23       Impact factor: 5.182

3.  Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

Authors:  Jaya Krishnan; Marianne Suter; Renata Windak; Tatiana Krebs; Allison Felley; Christophe Montessuit; Malgorzata Tokarska-Schlattner; Ellen Aasum; Anna Bogdanova; Evelyne Perriard; Jean-Claude Perriard; Terje Larsen; Thierry Pedrazzini; Wilhelm Krek
Journal:  Cell Metab       Date:  2009-06       Impact factor: 27.287

4.  Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis.

Authors:  Xiao-Qing Sun; Rui Zhang; Hong-Da Zhang; Ping Yuan; Xiao-Jian Wang; Qin-Hua Zhao; Lan Wang; Rong Jiang; Harm Jan Bogaard; Zhi-Cheng Jing
Journal:  Hypertens Res       Date:  2016-01-14       Impact factor: 3.872

5.  Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

Authors:  Michal K Handzlik; Dumitru Constantin-Teodosiu; Paul L Greenhaff; Mark A Cole
Journal:  J Physiol       Date:  2018-03-05       Impact factor: 5.182
  5 in total
  1 in total

Review 1.  Adaptive Cardiac Metabolism Under Chronic Hypoxia: Mechanism and Clinical Implications.

Authors:  Zhanhao Su; Yiwei Liu; Hao Zhang
Journal:  Front Cell Dev Biol       Date:  2021-02-02
  1 in total

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