Literature DB >> 29437623

Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.

Ziauddin Khan1,2, Suhail Ahmad3, Eiman Mokaddas1,4, Jacques F Meis5,6, Leena Joseph1, Aneesa Abdullah4, Sandhya Vayalil2.   

Abstract

Isolation of two echinocandin-resistant Candida tropicalis strains from endotracheal secretions of a patient following short-term exposure to caspofungin is described. Both strains exhibited resistance to echinocandins by Etest and reference broth microdilution, showing a homozygous S645P mutation within the hot spot 1 (HS-1) region of FKS1 and belonging to a unique multilocus sequence type. Other C. tropicalis isolates collected from patients in the same intensive care unit within a 60-day period were susceptible to echinocandins and contained wild-type FKS1 sequences.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Candida tropicalis; FKS1 mutations; echinocandins; genotyping; primary resistance

Mesh：

Substances：

Year:  2018        PMID： 29437623      PMCID： PMC5913946          DOI： 10.1128/AAC.01926-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  43 in total

1.  Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?

Authors:  A Espinel-Ingroff; M C Arendrup; M A Pfaller; L X Bonfietti; B Bustamante; E Canton; E Chryssanthou; M Cuenca-Estrella; E Dannaoui; A Fothergill; J Fuller; P Gaustad; G M Gonzalez; J Guarro; C Lass-Flörl; S R Lockhart; J F Meis; C B Moore; L Ostrosky-Zeichner; T Pelaez; S R B S Pukinskas; G St-Germain; M W Szeszs; J Turnidge
Journal:  Antimicrob Agents Chemother       Date:  2013-09-09       Impact factor: 5.191

Review 2.  Insights into Candida tropicalis nosocomial infections and virulence factors.

Authors:  M Negri; S Silva; M Henriques; R Oliveira
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-10-30       Impact factor: 3.267

3.  Changing epidemiology of candidaemia in Australia.

Authors:  Belinda Chapman; Monica Slavin; Debbie Marriott; Catriona Halliday; Sarah Kidd; Ian Arthur; Narin Bak; Christopher H Heath; Karina Kennedy; C Orla Morrissey; Tania C Sorrell; Sebastian van Hal; Caitlin Keighley; Emma Goeman; Neil Underwood; Krispin Hajkowicz; Ann Hofmeyr; Michael Leung; Nenad Macesic; Jeannie Botes; Christopher Blyth; Louise Cooley; C Robert George; Pankaja Kalukottege; Alison Kesson; Brendan McMullan; Robert Baird; Jennifer Robson; Tony M Korman; Stella Pendle; Kerry Weeks; Eunice Liu; Elaine Cheong; Sharon Chen
Journal:  J Antimicrob Chemother       Date:  2017-04-01       Impact factor: 5.790

4.  Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations.

Authors:  Rasmus Hare Jensen; Karen Marie Thyssen Astvad; Luis Vale Silva; Dominique Sanglard; Rene Jørgensen; Kristian Fog Nielsen; Estella Glintborg Mathiasen; Ghazalel Doroudian; David Scott Perlin; Maiken Cavling Arendrup
Journal:  J Antimicrob Chemother       Date:  2015-05-27       Impact factor: 5.790

5.  Antifungal susceptibility of clinical Candida parapsilosis isolates in Kuwait.

Authors:  Mohammad Asadzadeh; Noura A Al-Sweih; Suhail Ahmad; Zia U Khan
Journal:  Mycoses       Date:  2008-07       Impact factor: 4.377

6.  Multicenter study of epidemiological cutoff values and detection of resistance in Candida spp. to anidulafungin, caspofungin, and micafungin using the Sensititre YeastOne colorimetric method.

Authors:  A Espinel-Ingroff; M Alvarez-Fernandez; E Cantón; P L Carver; S C-A Chen; G Eschenauer; D L Getsinger; G M Gonzalez; N P Govender; A Grancini; K E Hanson; S E Kidd; K Klinker; C J Kubin; J V Kus; S R Lockhart; J Meletiadis; A J Morris; T Pelaez; G Quindós; M Rodriguez-Iglesias; F Sánchez-Reus; S Shoham; N L Wengenack; N Borrell Solé; J Echeverria; J Esperalba; E Gómez-G de la Pedrosa; I García García; M J Linares; F Marco; P Merino; J Pemán; L Pérez Del Molino; E Roselló Mayans; C Rubio Calvo; M Ruiz Pérez de Pipaon; G Yagüe; G Garcia-Effron; J Guinea; D S Perlin; M Sanguinetti; R Shields; J Turnidge
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

7.  Anidulafungin and micafungin MIC breakpoints are superior to that of caspofungin for identifying FKS mutant Candida glabrata strains and Echinocandin resistance.

Authors:  Ryan K Shields; M Hong Nguyen; Ellen G Press; Cassaundra L Updike; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2013-09-23       Impact factor: 5.191

8.  Genetic Drivers of Multidrug Resistance in Candida glabrata.

Authors:  Kelley R Healey; Cristina Jimenez Ortigosa; Erika Shor; David S Perlin
Journal:  Front Microbiol       Date:  2016-12-15       Impact factor: 5.640

9.  Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China.

Authors:  Jin-Yan Wu; Hong Guo; Hua-Min Wang; Guo-Hui Yi; Li-Min Zhou; Xiao-Wen He; Ying Zhang; Jianping Xu
Journal:  Sci Rep       Date:  2017-02-10       Impact factor: 4.379

10.  The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.

Authors:  Kelley R Healey; Yoji Nagasaki; Matthew Zimmerman; Milena Kordalewska; Steven Park; Yanan Zhao; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191
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  16 in total

1.  Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration.

Authors:  Elisabete Ricardo; Fréderic Grenouillet; Isabel M Miranda; Raquel M Silva; Guilluame Eglin; Nadège Devillard; Acácio Gonçalves Rodrigues; Cidália Pina-Vaz
Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.191

2.  ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait.

Authors:  Suhail Ahmad; Leena Joseph; Josie E Parker; Mohammad Asadzadeh; Steven L Kelly; Jacques F Meis; Ziauddin Khan
Journal:  Antimicrob Agents Chemother       Date:  2019-01-29       Impact factor: 5.191

Review 3.  Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics.

Authors:  Konstantin A Demin; Aleksandr G Refeld; Anna A Bogdanova; Evgenya V Prazdnova; Igor V Popov; Olga Yu Kutsevalova; Alexey M Ermakov; Anzhelica B Bren; Dmitry V Rudoy; Vladimir A Chistyakov; Richard Weeks; Michael L Chikindas
Journal:  Probiotics Antimicrob Proteins       Date:  2021-03-18       Impact factor: 4.609

4.  Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait.

Authors:  Mohammad Asadzadeh; Ahlam F Alanazi; Suhail Ahmad; Noura Al-Sweih; Ziauddin Khan
Journal:  PLoS One       Date:  2019-10-16       Impact factor: 3.240

5.  Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies.

Authors:  Maroun M Sfeir; Cristina Jiménez-Ortigosa; Maria N Gamaletsou; Audrey N Schuetz; Rosemary Soave; Koen Van Besien; Catherine B Small; David S Perlin; Thomas J Walsh
Journal:  J Fungi (Basel)       Date:  2020-01-31

6.  Antifungal drug susceptibility, molecular basis of resistance to echinocandins and molecular epidemiology of fluconazole resistance among clinical Candida glabrata isolates in Kuwait.

Authors:  Zahraa F Al-Baqsami; Suhail Ahmad; Ziauddin Khan
Journal:  Sci Rep       Date:  2020-04-10       Impact factor: 4.379

Review 7.  Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare Facilities.

Authors:  Suhail Ahmad; Wadha Alfouzan
Journal:  Microorganisms       Date:  2021-04-11

8.  Molecular Epidemiology of Candida Auris Outbreak in a Major Secondary-Care Hospital in Kuwait.

Authors:  Wadha Alfouzan; Suhail Ahmad; Rita Dhar; Mohammad Asadzadeh; Noura Almerdasi; Naglaa M Abdo; Leena Joseph; Theun de Groot; Walid Q Alali; Ziauddin Khan; Jacques F Meis; Mohammad R Al-Rashidi
Journal:  J Fungi (Basel)       Date:  2020-11-21

9.  Candida kefyr in Kuwait: Prevalence, antifungal drug susceptibility and genotypic heterogeneity.

Authors:  Suhail Ahmad; Ziauddin Khan; Noura Al-Sweih; Wadha Alfouzan; Leena Joseph; Mohammad Asadzadeh
Journal:  PLoS One       Date:  2020-10-27       Impact factor: 3.240

10.  Continual Decline in Azole Susceptibility Rates in Candida tropicalis Over a 9-Year Period in China.

Authors:  Yao Wang; Xin Fan; He Wang; Timothy Kudinha; Ya-Ning Mei; Fang Ni; Yu-Hong Pan; Lan-Mei Gao; Hui Xu; Hai-Shen Kong; Qing Yang; Wei-Ping Wang; Hai-Yan Xi; Yan-Ping Luo; Li-Yan Ye; Meng Xiao
Journal:  Front Microbiol       Date:  2021-07-09       Impact factor: 5.640
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