Literature DB >> 31932372

Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration.

Elisabete Ricardo1,2, Fréderic Grenouillet3,4, Isabel M Miranda5,6, Raquel M Silva7, Guilluame Eglin3, Nadège Devillard8, Acácio Gonçalves Rodrigues5,2,9, Cidália Pina-Vaz5,2.   

Abstract

Five Candida krusei isolates (susceptible and resistant) recovered from the urine of a kidney transplant patient treated with voriconazole (VRC) 200 mg twice daily for 20 days were studied. Eight unrelated clinical isolates of C. krusei were exposed in vitro to VRC 0.001 μg/ml for 30 days. Development of VRC transient resistance occurred in vivo, and induction of permanent resistance occurred in vitro Mostly, ABC1 and ERG11 genes were overexpressed, and a homozygous T418C mutation in the ERG11 gene was found.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  ABC1 ABC2 efflux pump genes; Candida krusei; ERG11 gene mutations; candidiasis; candiduria; mechanisms of antifungal resistance; underexposure to antifungal drugs; voriconazole

Mesh：

Substances：

Year:  2020        PMID： 31932372      PMCID： PMC7179295          DOI： 10.1128/AAC.01651-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  31 in total

1.  The disposition and metabolism of [14C]fluconazole in humans.

Authors:  K W Brammer; A J Coakley; S G Jezequel; M H Tarbit
Journal:  Drug Metab Dispos       Date:  1991 Jul-Aug       Impact factor: 3.922

Review 2.  Bladder irrigation with amphotericin B and fungal urinary tract infection--systematic review with meta-analysis.

Authors:  Felipe Francisco Tuon; Valdir Sabbaga Amato; Sergio Ricardo Penteado Filho
Journal:  Int J Infect Dis       Date:  2009-01-19       Impact factor: 3.623

Review 3.  Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

Authors:  Florent Morio; Cedric Loge; Bernard Besse; Christophe Hennequin; Patrice Le Pape
Journal:  Diagn Microbiol Infect Dis       Date:  2010-04       Impact factor: 2.803

4.  Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.

Authors:  P R Hunter; M A Gaston
Journal:  J Clin Microbiol       Date:  1988-11       Impact factor: 5.948

5.  Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.

Authors:  Ziauddin Khan; Suhail Ahmad; Eiman Mokaddas; Jacques F Meis; Leena Joseph; Aneesa Abdullah; Sandhya Vayalil
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

6.  Aneuploidy and isochromosome formation in drug-resistant Candida albicans.

Authors:  Anna Selmecki; Anja Forche; Judith Berman
Journal:  Science       Date:  2006-07-21       Impact factor: 47.728

Review 7.  Voriconazole: a new triazole antifungal agent.

Authors:  Leonard B Johnson; Carol A Kauffman
Journal:  Clin Infect Dis       Date:  2003-02-10       Impact factor: 9.079

8.  Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.

Authors:  Alix Coste; Anna Selmecki; Anja Forche; Dorothée Diogo; Marie-Elisabeth Bougnoux; Christophe d'Enfert; Judith Berman; Dominique Sanglard
Journal:  Eukaryot Cell       Date:  2007-08-10

9.  The evolution of drug resistance in clinical isolates of Candida albicans.

Authors:  Christopher B Ford; Jason M Funt; Darren Abbey; Luca Issi; Candace Guiducci; Diego A Martinez; Toni Delorey; Bi Yu Li; Theodore C White; Christina Cuomo; Reeta P Rao; Judith Berman; Dawn A Thompson; Aviv Regev
Journal:  Elife       Date:  2015-02-03       Impact factor: 8.140

10.  Whole Genome Sequence of the Heterozygous Clinical Isolate Candida krusei 81-B-5.

Authors:  Christina A Cuomo; Terrance Shea; Bo Yang; Reeta Rao; Anja Forche
Journal:  G3 (Bethesda)       Date:  2017-09-07       Impact factor: 3.154
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  2 in total

1.  In Vitro Activity of Manogepix against Multidrug-Resistant and Panresistant Candida auris from the New York Outbreak.

Authors:  YanChun Zhu; Shannon Kilburn; Mili Kapoor; Sudha Chaturvedi; Karen Joy Shaw; Vishnu Chaturvedi
Journal:  Antimicrob Agents Chemother       Date:  2020-10-20       Impact factor: 5.191

2.  Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candida krusei Recovered from an International Collection.

Authors:  Hazim O Khalifa; Vit Hubka; Akira Watanabe; Minoru Nagi; Yoshitsugu Miyazaki; Takashi Yaguchi; Katsuhiko Kamei
Journal:  Antimicrob Agents Chemother       Date:  2021-12-06       Impact factor: 5.938
  2 in total

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