XiaoDong Yuan1, Wei Tang2,3, WenWei Shi4, Libao Yu5, Jing Zhang4, Qing Yuan6, Shan You4, Ning Wu4, Guokun Ao4, Tingting Ma4. 1. Department of Radiology, the 309th Hospital of Chinese People's Liberation Army, 17 Heishanhu Road, Haidian District, Beijing, 100091, People's Republic of China. yuanxiaodongzj@163.com. 2. Department of Radiology, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, People's Republic of China. 3. Department of Oncology, Shanghai Medical College, Fudan University, 270 Dongan Road, Shanghai, 200032, People's Republic of China. 4. Department of Radiology, the 309th Hospital of Chinese People's Liberation Army, 17 Heishanhu Road, Haidian District, Beijing, 100091, People's Republic of China. 5. Department of Hepatobiliary Surgery, the 309th Hospital of Chinese People's Liberation Army, 17 Heishanhu Road, Haidian District, Beijing, 100091, People's Republic of China. 6. Department of Urology, the 309th Hospital of Chinese People's Liberation Army, 17 Heishanhu Road, Haidian District, Beijing, 100091, People's Republic of China.
Abstract
OBJECTIVES: To develop a convenient and rapid single-kidney CT-GFR technique. METHODS:One hundred and twelve patients referred for multiphasic renal CT and 99mTc-DTPArenal dynamic imaging Gates-GFR measurement were prospectively included and randomly divided into two groups of 56 patients each: the training group and the validation group. On the basis of the nephrographic phase images, the fractional renal accumulation (FRA) was calculated and correlated with the Gates-GFR in the training group. From this correlation a formula was derived for single-kidney CT-GFR calculation, which was validated by a paired t test and linear regression analysis with the single-kidney Gates-GFR in the validation group. RESULTS: In the training group, the FRA (x-axis) correlated well (r = 0.95, p < 0.001) with single-kidney Gates-GFR (y-axis), producing a regression equation of y = 1665x + 1.5 for single-kidney CT-GFR calculation. In the validation group, the difference between the methods of single-kidney GFR measurements was 0.38 ± 5.57 mL/min (p = 0.471); the regression line is identical to the diagonal (intercept = 0 and slope = 1) (p = 0.727 and p = 0.473, respectively), with a standard deviation of residuals of 5.56 mL/min. CONCLUSION: A convenient and rapid single-kidney CT-GFR technique was presented and validated in this investigation. KEY POINTS: • The new CT-GFR method takes about 2.5 min of patient time. • The CT-GFR method demonstrated identical results to the Gates-GFR method. • The CT-GFR method is based on the fractional renal accumulation of iodinated CM. • The CT-GFR method is achieved without additional radiation dose to the patient.
RCT Entities:
OBJECTIVES: To develop a convenient and rapid single-kidney CT-GFR technique. METHODS: One hundred and twelve patients referred for multiphasic renal CT and 99mTc-DTPA renal dynamic imaging Gates-GFR measurement were prospectively included and randomly divided into two groups of 56 patients each: the training group and the validation group. On the basis of the nephrographic phase images, the fractional renal accumulation (FRA) was calculated and correlated with the Gates-GFR in the training group. From this correlation a formula was derived for single-kidney CT-GFR calculation, which was validated by a paired t test and linear regression analysis with the single-kidney Gates-GFR in the validation group. RESULTS: In the training group, the FRA (x-axis) correlated well (r = 0.95, p < 0.001) with single-kidney Gates-GFR (y-axis), producing a regression equation of y = 1665x + 1.5 for single-kidney CT-GFR calculation. In the validation group, the difference between the methods of single-kidney GFR measurements was 0.38 ± 5.57 mL/min (p = 0.471); the regression line is identical to the diagonal (intercept = 0 and slope = 1) (p = 0.727 and p = 0.473, respectively), with a standard deviation of residuals of 5.56 mL/min. CONCLUSION: A convenient and rapid single-kidney CT-GFR technique was presented and validated in this investigation. KEY POINTS: • The new CT-GFR method takes about 2.5 min of patient time. • The CT-GFR method demonstrated identical results to the Gates-GFR method. • The CT-GFR method is based on the fractional renal accumulation of iodinated CM. • The CT-GFR method is achieved without additional radiation dose to the patient.
Authors: Andreas Helck; Wieland H Sommer; Ernst Klotz; Matthias Wessely; Steven Pieter Sourbron; Konstantin Nikolaou; Dirk A Clevert; Mike Notohamiprodjo; Wolf D Illner; Maximilian Reiser; Hans-Christoph Becker Journal: Invest Radiol Date: 2010-07 Impact factor: 6.016
Authors: N G De Santo; P Anastasio; M Cirillo; D Santoro; L Spitali; L Mansi; L Celentano; D Capodicasa; E Cirillo; E Del Vecchio; C Pascale; G Capasso Journal: Nephron Date: 1999-02 Impact factor: 2.847
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