OBJECTIVES: To determine the feasibility of a dynamic CT angiography-protocol in regard to simultaneous assessment of morphology and function. METHOD AND MATERIALS: Fourteen patients with renal graft dysfunction received a dynamic computed tomography angiography (CTA) using a 128-slice CT-scanner with continuous bi-directional table movement, allowing to cover a scan range of 18 cm within 1.75 seconds. Twelve scans of the entire kidney were acquired every 3.5 seconds with the aim to simultaneously obtain CTA and renal function data. The glomerular filtration rate (GFR) was calculated by a modified Patlak method and compared with creatinine-based formulas (MDRD 4 and endogenous creatinine clearance), that served as reference standard. RESULTS: GFR obtained from dynamic CTA correlates well with the GFR derived by creatinine-based formulas with a correlation coefficient of r = 0.8986; P < 0.0001. The average absolute deviation was 8.1 mL/min. The mean amount of contrast medium required was 35 mL. The average effective dose was 13.8 mSv. CONCLUSION: Dynamic CTA offers the possibility to determine the GFR and thus facilitates simultaneous assessment of morphology and function. Additionally, our dynamic CTA-protocol helps to significantly reduce the amount of contrast medium, which is beneficial for patients with impaired renal function.
OBJECTIVES: To determine the feasibility of a dynamic CT angiography-protocol in regard to simultaneous assessment of morphology and function. METHOD AND MATERIALS: Fourteen patients with renal graft dysfunction received a dynamic computed tomography angiography (CTA) using a 128-slice CT-scanner with continuous bi-directional table movement, allowing to cover a scan range of 18 cm within 1.75 seconds. Twelve scans of the entire kidney were acquired every 3.5 seconds with the aim to simultaneously obtain CTA and renal function data. The glomerular filtration rate (GFR) was calculated by a modified Patlak method and compared with creatinine-based formulas (MDRD 4 and endogenous creatinine clearance), that served as reference standard. RESULTS: GFR obtained from dynamic CTA correlates well with the GFR derived by creatinine-based formulas with a correlation coefficient of r = 0.8986; P < 0.0001. The average absolute deviation was 8.1 mL/min. The mean amount of contrast medium required was 35 mL. The average effective dose was 13.8 mSv. CONCLUSION: Dynamic CTA offers the possibility to determine the GFR and thus facilitates simultaneous assessment of morphology and function. Additionally, our dynamic CTA-protocol helps to significantly reduce the amount of contrast medium, which is beneficial for patients with impaired renal function.
Authors: Andreas Helck; Ulf Schönermarck; Antje Habicht; Mike Notohamiprodjo; Manfred Stangl; Ernst Klotz; Konstantin Nikolaou; Christian la Fougère; Dirk Andrè Clevert; Maximilian Reiser; Christoph Becker Journal: PLoS One Date: 2014-03-11 Impact factor: 3.240
Authors: K A Miles; T-Y Lee; V Goh; E Klotz; C Cuenod; S Bisdas; A M Groves; M P Hayball; R Alonzi; T Brunner Journal: Eur Radiol Date: 2012-02-26 Impact factor: 5.315