Aniruddha Ray1, Xueding Wang2, Yong-Eun Koo Lee3, Hoe Jin Hah3, Gwangseong Kim3, Thomas Chen4, Daniel A Orringer4, Oren Sagher4, Xiaojun Liu5, Raoul Kopelman1,3. 1. Biophysics, University of Michigan, Ann Arbor, MI 48109, USA. 2. Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA. 3. Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. 4. Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA. 5. Institute of Acoustics, Nanjing University, Nanjing 210093, China.
Abstract
Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water (equivalent to 0.84 μmol/L Coomassie Blue dye). The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.
Distinguishing a n class="Disease">tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water (equivalent to 0.84 μmol/L Coomassie Blue dye). The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.
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