Literature DB >> 29410534

Reimagining the diagnostic pathway for gastrointestinal cancer.

Greg Rubin1, Fiona Walter2, Jon Emery3, Niek de Wit4.   

Abstract

A crisis is looming for the diagnosis of gastrointestinal cancers, one grounded only partly in the steady increase in their overall incidence. Public demand for diagnostic tests to be undertaken early and at lower levels of risk is reflected in early diagnosis being a widely held policy objective for reasons of both clinical outcome and patient experience. In the UK, urgent referrals for suspected lower gastrointestinal cancer have increased by 78% in the past 6 years, with parallel increases in endoscopy and imaging activity. Such growth in demand is unsustainable with current models of care. If gastrointestinal cancer diagnosis is to be affordable, the roles of professionals and their interactions with each other will need to be reframed while retaining public confidence in the process. In this Perspective, we consider how the relationship between medical specialists and generalists could be redefined to make better use of the skills of each while delivering optimal clinical outcomes and a good patient experience.

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Year:  2018        PMID: 29410534     DOI: 10.1038/nrgastro.2018.1

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN: 1759-5045            Impact factor:   46.802


  64 in total

Review 1.  The expanding role of primary care in cancer control.

Authors:  Greg Rubin; Annette Berendsen; S Michael Crawford; Rachel Dommett; Craig Earle; Jon Emery; Tom Fahey; Luigi Grassi; Eva Grunfeld; Sumit Gupta; Willie Hamilton; Sara Hiom; David Hunter; Georgios Lyratzopoulos; Una Macleod; Robert Mason; Geoffrey Mitchell; Richard D Neal; Michael Peake; Martin Roland; Bohumil Seifert; Jeff Sisler; Jonathan Sussman; Stephen Taplin; Peter Vedsted; Teja Voruganti; Fiona Walter; Jane Wardle; Eila Watson; David Weller; Richard Wender; Jeremy Whelan; James Whitlock; Clare Wilkinson; Niek de Wit; Camilla Zimmermann
Journal:  Lancet Oncol       Date:  2015-09       Impact factor: 41.316

2.  Leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer.

Authors:  Manasi S Shah; Todd Z DeSantis; Thomas Weinmaier; Paul J McMurdie; Julia L Cope; Adam Altrichter; Jose-Miguel Yamal; Emily B Hollister
Journal:  Gut       Date:  2017-03-24       Impact factor: 23.059

3.  Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.

Authors:  Joshua D Cohen; Ammar A Javed; Christopher Thoburn; Fay Wong; Jeanne Tie; Peter Gibbs; C Max Schmidt; Michele T Yip-Schneider; Peter J Allen; Mark Schattner; Randall E Brand; Aatur D Singhi; Gloria M Petersen; Seung-Mo Hong; Song Cheol Kim; Massimo Falconi; Claudio Doglioni; Matthew J Weiss; Nita Ahuja; Jin He; Martin A Makary; Anirban Maitra; Samir M Hanash; Marco Dal Molin; Yuxuan Wang; Lu Li; Janine Ptak; Lisa Dobbyn; Joy Schaefer; Natalie Silliman; Maria Popoli; Michael G Goggins; Ralph H Hruban; Christopher L Wolfgang; Alison P Klein; Cristian Tomasetti; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Anne Marie Lennon
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-05       Impact factor: 11.205

4.  Symptoms and risk factors to identify women with suspected cancer in primary care: derivation and validation of an algorithm.

Authors:  Julia Hippisley-Cox; Carol Coupland
Journal:  Br J Gen Pract       Date:  2013-01       Impact factor: 5.386

5.  Symptoms and risk factors to identify men with suspected cancer in primary care: derivation and validation of an algorithm.

Authors:  Julia Hippisley-Cox; Carol Coupland
Journal:  Br J Gen Pract       Date:  2013-01       Impact factor: 5.386

6.  Explaining variation in cancer survival between 11 jurisdictions in the International Cancer Benchmarking Partnership: a primary care vignette survey.

Authors:  Peter W Rose; Greg Rubin; Rafael Perera-Salazar; Sigrun Saur Almberg; Andriana Barisic; Martin Dawes; Eva Grunfeld; Nigel Hart; Richard D Neal; Marie Pirotta; Jeffrey Sisler; Gerald Konrad; Berit Skjødeberg Toftegaard; Hans Thulesius; Peter Vedsted; Jane Young; Willie Hamilton
Journal:  BMJ Open       Date:  2015-05-27       Impact factor: 2.692

7.  Cancer incidence and mortality projections in the UK until 2035.

Authors:  C R Smittenaar; K A Petersen; K Stewart; N Moitt
Journal:  Br J Cancer       Date:  2016-10-11       Impact factor: 7.640

8.  Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11 720 patients in five countries.

Authors:  M L Tørring; P Murchie; W Hamilton; P Vedsted; M Esteva; M Lautrup; M Winget; G Rubin
Journal:  Br J Cancer       Date:  2017-08-08       Impact factor: 7.640

9.  Cancer suspicion in general practice, urgent referral and time to diagnosis: a population-based GP survey and registry study.

Authors:  Henry Jensen; Marie Louise Tørring; Frede Olesen; Jens Overgaard; Peter Vedsted
Journal:  BMC Cancer       Date:  2014-08-30       Impact factor: 4.430

10.  Is there an added value of faecal calprotectin and haemoglobin in the diagnostic work-up for primary care patients suspected of significant colorectal disease? A cross-sectional diagnostic study.

Authors:  Sjoerd G Elias; Liselotte Kok; Niek J de Wit; Ben J M Witteman; Jelle G Goedhard; Mariëlle J L Romberg-Camps; Jean W M Muris; Karel G M Moons
Journal:  BMC Med       Date:  2016-09-26       Impact factor: 8.775

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  9 in total

1.  Evaluating diagnostic strategies for early detection of cancer: the CanTest framework.

Authors:  Fiona M Walter; Matthew J Thompson; Ian Wellwood; Gary A Abel; William Hamilton; Margaret Johnson; Georgios Lyratzopoulos; Michael P Messenger; Richard D Neal; Greg Rubin; Hardeep Singh; Anne Spencer; Stephen Sutton; Peter Vedsted; Jon D Emery
Journal:  BMC Cancer       Date:  2019-06-14       Impact factor: 4.430

2.  Time to diagnosis of symptomatic gastric and oesophageal cancer in the Netherlands: Where is the room for improvement?

Authors:  N F van Erp; C W Helsper; P Slottje; D Brandenbarg; F L Büchner; K M van Asselt; Jwm Muris; M F Kortekaas; Phm Peeters; N J de Wit
Journal:  United European Gastroenterol J       Date:  2020-04-06       Impact factor: 4.623

Review 3.  Opportunities for Conventional and in Situ Cancer Vaccine Strategies and Combination with Immunotherapy for Gastrointestinal Cancers, A Review.

Authors:  Rachid Bouzid; Maikel Peppelenbosch; Sonja I Buschow
Journal:  Cancers (Basel)       Date:  2020-04-30       Impact factor: 6.639

4.  Association between use of urgent suspected cancer referral and mortality and stage at diagnosis: a 5-year national cohort study.

Authors:  Thomas Round; Carolynn Gildea; Mark Ashworth; Henrik Møller
Journal:  Br J Gen Pract       Date:  2020-05-28       Impact factor: 5.386

Review 5.  Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Upper Gastrointestinal Cancers: A Systematic Review.

Authors:  Natalia Calanzani; Paige E Druce; Claudia Snudden; Kristi M Milley; Rachel Boscott; Dawnya Behiyat; Smiji Saji; Javiera Martinez-Gutierrez; Jasmeen Oberoi; Garth Funston; Mike Messenger; Jon Emery; Fiona M Walter
Journal:  Adv Ther       Date:  2020-12-11       Impact factor: 3.845

6.  Conceptual Framework to Guide Early Diagnosis Programs for Symptomatic Cancer as Part of Global Cancer Control.

Authors:  Minjoung Monica Koo; Karla Unger-Saldaña; Amos D Mwaka; Marilys Corbex; Ophira Ginsburg; Fiona M Walter; Natalia Calanzani; Jennifer Moodley; Greg P Rubin; Georgios Lyratzopoulos
Journal:  JCO Glob Oncol       Date:  2021-01

7.  Recognising Colorectal Cancer in Primary Care.

Authors:  Natalia Calanzani; Aina Chang; Marije Van Melle; Merel M Pannebakker; Garth Funston; Fiona M Walter
Journal:  Adv Ther       Date:  2021-04-17       Impact factor: 3.845

8.  Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.

Authors:  Paige Druce; Natalia Calanzani; Claudia Snudden; Kristi Milley; Rachel Boscott; Dawnya Behiyat; Javiera Martinez-Gutierrez; Smiji Saji; Jasmeen Oberoi; Garth Funston; Mike Messenger; Fiona M Walter; Jon Emery
Journal:  Adv Ther       Date:  2021-04-27       Impact factor: 3.845

9.  The SYMPTOM-upper gastrointestinal study: A mixed methods study exploring symptom appraisal and help-seeking in Australian upper gastrointestinal cancer patients.

Authors:  Napin Karnchanachari; Shakira Milton; Tjuntu Muhlen-Schulte; Riati Scarborough; Jennifer F Holland; Fiona M Walter; John Zalcberg; Jon Emery
Journal:  Eur J Cancer Care (Engl)       Date:  2022-05-06       Impact factor: 2.328

  9 in total

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