PURPOSE: The water drinking test (WDT) is currently used to temporarily elevate intraocular pressure (IOP) and predict peak IOP in glaucoma. This study investigates neurovascular changes associated with WDT in normal subjects. METHODS: The effect of WDT (1 L in 5 min) on IOP, mean brachial blood pressure, heart rate, and pattern electroretinogram was assessed within the next hour in 16 healthy subjects (mean age: 33.5±7.9 y). As a control, testing was repeated in the same subjects without WDT 1 week later. RESULTS: Compared with control, WDT resulted in significant peak changes of the following parameters compared with baseline: IOP: +1.7±1.8 mm Hg after 30', mean brachial blood pressure: +3.9±6.3 mm Hg after 15'; heart rate: -9.2±9.8 bpm after 15', pattern electroretinogram latency: +2.1±0.9 ms after 15'. CONCLUSIONS: In addition to IOP elevation, WDT was associated with significant changes of hemodynamic parameters and retinal ganglion cell function in young healthy subjects. As these represent risk factors for glaucoma, their assessment upon WDT might increase its predictive power for glaucoma development.
PURPOSE: The water drinking test (WDT) is currently used to temporarily elevate intraocular pressure (IOP) and predict peak IOP in glaucoma. This study investigates neurovascular changes associated with WDT in normal subjects. METHODS: The effect of WDT (1 L in 5 min) on IOP, mean brachial blood pressure, heart rate, and pattern electroretinogram was assessed within the next hour in 16 healthy subjects (mean age: 33.5±7.9 y). As a control, testing was repeated in the same subjects without WDT 1 week later. RESULTS: Compared with control, WDT resulted in significant peak changes of the following parameters compared with baseline: IOP: +1.7±1.8 mm Hg after 30', mean brachial blood pressure: +3.9±6.3 mm Hg after 15'; heart rate: -9.2±9.8 bpm after 15', pattern electroretinogram latency: +2.1±0.9 ms after 15'. CONCLUSIONS: In addition to IOP elevation, WDT was associated with significant changes of hemodynamic parameters and retinal ganglion cell function in young healthy subjects. As these represent risk factors for glaucoma, their assessment upon WDT might increase its predictive power for glaucoma development.
Authors: Patricia Martinez; Valerie Trubnik; Benjamin E Leiby; Sarah E Hegarty; Reza Razeghinejad; Shravan Savant; Jonathan S Myers Journal: J Glaucoma Date: 2017-02 Impact factor: 2.503
Authors: P Monsalve; S Ren; G Triolo; L Vazquez; A D Henderson; M Kostic; P Gordon; W J Feuer; V Porciatti Journal: Doc Ophthalmol Date: 2018-05-19 Impact factor: 2.379
Authors: Maja Kostic; Phillip Gordon; Pedro Monsalve; Hong Jang; Byron L Lam; John Guy; John McSoley; Luis Vazquez; Elizabeth Hodapp; Vittorio Porciatti Journal: Curr Eye Res Date: 2020-06-04 Impact factor: 2.424