Özcan Özdamar1, Jonathon Toft-Nielsen2, Jorge Bohórquez2, Vittorio Porciatti3. 1. University of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States University of Miami, Departments of Otolaryngology, Pediatrics, and Neuroscience (Graduate), Miami, Florida, United States. 2. University of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States. 3. University of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States University of Miami, Bascom Palmer Eye Institute, Miami, Florida, United States.
Abstract
PURPOSE: We determined if the overlap of transient (tr) pattern electroretinograms (PERG(tr)) can explain the generation of the steady-state (SS) pattern electroretinogram (PERG(SS)), and investigated the relationship between the two types of responses. METHODS: Slightly jittered pattern reversals were used to generate quasi SS (QSS) PERG(SS) responses from eight normal subjects, recorded using lower eyelid skin electrodes, at rates between 6.9 and 26.5 reversals per second (rps). Jittered quasi PERG(SS) were deconvolved using the frequency domain continuous loop averaging deconvolution method. Additionally, conventional PERG(tr) at 2.2 rps and PERG(SS) at each of the QSS stimulation rates were obtained from all subjects. Two synthetic PERG(SS) responses were constructed at each stimulation rate, one using the PERG(tr) obtained at that rate, and the other using the conventional 2.2 rps PERG(tr). Synthetic responses then were compared to the recorded PERG(SS) using amplitude, latency, and spectral measurements. RESULTS: Findings indicate that the PERG(SS) obtained at SS rates can be predicted using the superposition of deconvolved tr PERGs at each particular rate. Although conventional PERG(tr) can explain PERG(SS) obtained at rates below 15.4 rps (≥ 97% correlation), for higher reversal rates only deconvolved responses obtained at that rate can produce the recorded SS responses (96% vs. 65% correlation at 26.5 rps). CONCLUSIONS: The study shows that PERG(SS) results from the overlapping of tr PERG(tr) waveforms generated at that reversal rate. The first two peaks (N(SS) and P(SS)) of the PERG(SS) reflect N35 and P50 waves of the tr PERG(tr). The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERG(SS) amplitude. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: We determined if the overlap of transient (tr) pattern electroretinograms (PERG(tr)) can explain the generation of the steady-state (SS) pattern electroretinogram (PERG(SS)), and investigated the relationship between the two types of responses. METHODS: Slightly jittered pattern reversals were used to generate quasi SS (QSS) PERG(SS) responses from eight normal subjects, recorded using lower eyelid skin electrodes, at rates between 6.9 and 26.5 reversals per second (rps). Jittered quasi PERG(SS) were deconvolved using the frequency domain continuous loop averaging deconvolution method. Additionally, conventional PERG(tr) at 2.2 rps and PERG(SS) at each of the QSS stimulation rates were obtained from all subjects. Two synthetic PERG(SS) responses were constructed at each stimulation rate, one using the PERG(tr) obtained at that rate, and the other using the conventional 2.2 rps PERG(tr). Synthetic responses then were compared to the recorded PERG(SS) using amplitude, latency, and spectral measurements. RESULTS: Findings indicate that the PERG(SS) obtained at SS rates can be predicted using the superposition of deconvolved tr PERGs at each particular rate. Although conventional PERG(tr) can explain PERG(SS) obtained at rates below 15.4 rps (≥ 97% correlation), for higher reversal rates only deconvolved responses obtained at that rate can produce the recorded SS responses (96% vs. 65% correlation at 26.5 rps). CONCLUSIONS: The study shows that PERG(SS) results from the overlapping of tr PERG(tr) waveforms generated at that reversal rate. The first two peaks (N(SS) and P(SS)) of the PERG(SS) reflect N35 and P50 waves of the tr PERG(tr). The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERG(SS) amplitude. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Authors: Lori M Ventura; Iuri Golubev; William Lee; Izuru Nose; Jean-Marie Parel; William J Feuer; Vittorio Porciatti Journal: J Glaucoma Date: 2013-03 Impact factor: 2.503
Authors: Vittorio Porciatti; Brandon Bosse; Prashant K Parekh; Olga A Shif; William J Feuer; Lori M Ventura Journal: J Glaucoma Date: 2014 Oct-Nov Impact factor: 2.503
Authors: Pantea Moghimi; Nathalia Torres Jimenez; Linda K McLoon; Theoden I Netoff; Michael S Lee; Angus MacDonald; Robert F Miller Journal: Schizophr Res Date: 2019-10-12 Impact factor: 4.939
Authors: P Monsalve; S Ren; G Triolo; L Vazquez; A D Henderson; M Kostic; P Gordon; W J Feuer; V Porciatti Journal: Doc Ophthalmol Date: 2018-05-19 Impact factor: 2.379
Authors: Vittorio Porciatti; Diego E Alba; William J Feuer; Janet Davis; John Guy; Byron L Lam Journal: Transl Vis Sci Technol Date: 2022-03-02 Impact factor: 3.283