Xi Zhang1, Qiang Tian2, Liang Wang3, Yang Liu1, Baojuan Li1, Zhengrong Liang4, Peng Gao1, Kaizhong Zheng1, Bofeng Zhao2, Hongbing Lu1. 1. Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China. 2. Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China. 3. Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China. 4. Departments of Radiology, Computer Science and Biomedical Engineering, State University of New York, Stony Brook, New York, USA.
Abstract
BACKGROUND: Noninvasive detection of isocitrate dehydrogenase (IDH) and TP53 mutations are meaningful for molecular stratification of lower-grade gliomas (LrGG). PURPOSE: To explore potential MRI features reflecting IDH and TP53 mutations of LrGG, and propose a radiomics strategy for detecting them. STUDY TYPE: Retrospective, radiomics. POPULATION/ SUBJECTS: A total of 103 LrGG patients were separated into development (n = 73) and validation (n = 30) cohorts. FIELD STRENGTH/SEQUENCE: T1 -weighted (before and after contrast-enhanced), T2 -weighted, and fluid-attenuation inversion recovery images from 1.5T (n = 37) or 3T (n = 66) scanners. ASSESSMENT: After data preprocessing, high-throughput features were derived from patients' volumes of interests of different sequences. The support vector machine-based recursive feature elimination (SVM-RFE) was adopted to find the optimal features for IDH and TP53 mutation detection. SVM models were trained and tested on development and validation cohort. The commonly used metric was used for assessing the efficiency. STATISTICAL TESTS: One-way analysis of variance (ANOVA), chi-square, or Fisher's exact test were applied on clinical characteristics to confirm whether significant differences exist between three molecular subtypes decided by IDH and TP53 status. Intraclass correlation coefficients were calculated to assess the robustness of the radiomics features. RESULTS: The constituent ratio of histopathologic subtypes was significantly different among three molecular subtypes (P = 0.017). SVM models for detecting IDH and TP53 mutation were established using 12 and 22 optimal features selected by SVM-RFE. The accuracies and area under the curves for IDH and TP53 mutations on the development cohort were 84.9%, 0.830, and 92.0%, 0.949, while on the validation cohort were 80.0%, 0.792, and 85.0%, 0.869, respectively. Furthermore, the stratified accuracies of three subtypes were 72.8%, 71.9%, and 70%, respectively. DATA CONCLUSION: Using a radiomics approach integrating SVM model and multimodal MRI features, molecular subtype stratification of LGG patients was implemented through detecting IDH and TP53 mutations. The results suggested that the proposed approach has promising detecting efficiency and T2 -weighted image features are more important than features from other images. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:916-926.
BACKGROUND: Noninvasive detection of isocitrate dehydrogenase (IDH) and TP53 mutations are meaningful for molecular stratification of lower-grade gliomas (LrGG). PURPOSE: To explore potential MRI features reflecting IDH and TP53 mutations of LrGG, and propose a radiomics strategy for detecting them. STUDY TYPE: Retrospective, radiomics. POPULATION/ SUBJECTS: A total of 103 LrGG patients were separated into development (n = 73) and validation (n = 30) cohorts. FIELD STRENGTH/SEQUENCE: T1 -weighted (before and after contrast-enhanced), T2 -weighted, and fluid-attenuation inversion recovery images from 1.5T (n = 37) or 3T (n = 66) scanners. ASSESSMENT: After data preprocessing, high-throughput features were derived from patients' volumes of interests of different sequences. The support vector machine-based recursive feature elimination (SVM-RFE) was adopted to find the optimal features for IDH and TP53 mutation detection. SVM models were trained and tested on development and validation cohort. The commonly used metric was used for assessing the efficiency. STATISTICAL TESTS: One-way analysis of variance (ANOVA), chi-square, or Fisher's exact test were applied on clinical characteristics to confirm whether significant differences exist between three molecular subtypes decided by IDH and TP53 status. Intraclass correlation coefficients were calculated to assess the robustness of the radiomics features. RESULTS: The constituent ratio of histopathologic subtypes was significantly different among three molecular subtypes (P = 0.017). SVM models for detecting IDH and TP53 mutation were established using 12 and 22 optimal features selected by SVM-RFE. The accuracies and area under the curves for IDH and TP53 mutations on the development cohort were 84.9%, 0.830, and 92.0%, 0.949, while on the validation cohort were 80.0%, 0.792, and 85.0%, 0.869, respectively. Furthermore, the stratified accuracies of three subtypes were 72.8%, 71.9%, and 70%, respectively. DATA CONCLUSION: Using a radiomics approach integrating SVM model and multimodal MRI features, molecular subtype stratification of LGG patients was implemented through detecting IDH and TP53 mutations. The results suggested that the proposed approach has promising detecting efficiency and T2 -weighted image features are more important than features from other images. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:916-926.
Authors: Sahil Nalawade; Gowtham K Murugesan; Maryam Vejdani-Jahromi; Ryan A Fisicaro; Chandan G Bangalore Yogananda; Ben Wagner; Bruce Mickey; Elizabeth Maher; Marco C Pinho; Baowei Fei; Ananth J Madhuranthakam; Joseph A Maldjian Journal: J Med Imaging (Bellingham) Date: 2019-12-10
Authors: Minjae Kim; So Yeong Jung; Ji Eun Park; Yeongheun Jo; Seo Young Park; Soo Jung Nam; Jeong Hoon Kim; Ho Sung Kim Journal: Eur Radiol Date: 2019-12-11 Impact factor: 5.315