Literature DB >> 293737

Human heterozygosity: a new estimate.

E H McConkey, B J Taylor, D Phan.   

Abstract

Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.

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Year:  1979        PMID： 293737      PMCID： PMC411893          DOI： 10.1073/pnas.76.12.6500

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Genetically controlled variation in the shapes of enzymes.

Authors:  G Johnson
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1979

2.  Reevaluation of level of genic heterozygosity in natural population of Drosophila melanogaster by two-dimensional electrophoresis.

Authors:  A J Brown; C H Langley
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

3.  Tissue-specific differences in cultured human diploid fibroblasts.

Authors:  E L Schneider; Y Mitsui; K S Au; S S Shorr
Journal:  Exp Cell Res       Date:  1977-08       Impact factor: 3.905

4.  Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy.

Authors:  H Harris; D A Hopkinson; Y H Edwards
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

5.  High resolution two-dimensional electrophoresis of human plasma proteins.

Authors:  L Anderson; N G Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

6.  Stuttering: high-level mistranslation in animal and bacterial cells.

Authors:  J Parker; J W Pollard; J D Friesen; C P Stanners
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

7.  Genetic polymorphism in normal human fibroblasts as analyzed by two-dimensional polyacrylamide gel electrophoresis.

Authors:  K E Walton; D Styer; E I Gruenstein
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

8.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

9.  Double-label autoradiography for comparison of complex protein mixtures after gel electrophoresis.

Authors:  E H McConkey
Journal:  Anal Biochem       Date:  1979-07-01       Impact factor: 3.365

10.  Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells.

Authors:  R A Steinberg; P H O'Farrell; U Friedrich; P Coffino
Journal:  Cell       Date:  1977-03       Impact factor: 41.582
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  33 in total

1.  Is the polymorphism of protein amounts related to phenotypic variability? A comparison of two-dimensional electrophoresis data with morphological traits in maize.

Authors:  C Damerval; Y Hébert; D de Vienne
Journal:  Theor Appl Genet       Date:  1987-06       Impact factor: 5.699

2.  Identification of frankia strains by two-dimensional polyacrylamide gel electrophoresis.

Authors:  D R Benson; S E Buchholz; D G Hanna
Journal:  Appl Environ Microbiol       Date:  1984-03       Impact factor: 4.792

3.  Average locus differences in mutability related to protein "class": a hypothesis.

Authors:  J V Neel
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

4.  Heterozygosity and ethnic variation in Japanese platelet proteins.

Authors:  J Asakawa; J V Neel; N Takahashi; C Satoh; S Kaneoka; E Nishikori; M Fujita
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

5.  The sensitivity of isoelectric focusing and electrophoresis in the detection of sequence differences in proteins.

Authors:  T McLellan; L S Inouye
Journal:  Biochem Genet       Date:  1986-08       Impact factor: 1.890

6.  Genetic variants detected among 106 lymphocyte polypeptides observed in two-dimensional gels.

Authors:  S M Hanash; L J Baier; D Welch; R Kuick; M Galteau
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025

7.  Human lymphocyte polymorphisms detected by quantitative two-dimensional electrophoresis.

Authors:  D Goldman; C R Merril
Journal:  Am J Hum Genet       Date:  1983-09       Impact factor: 11.025

8.  Two-dimensional electrophoresis of soluble and structure-bound proteins from cultured human fibroblasts and hair root cells: qualitative and quantitative variation.

Authors:  J Klose; I Willers; S Singh; H W Goedde
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

9.  Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 3. Frequent occurrence of genetic variants in some abundant polypeptides of PHA-stimulated peripheral blood lymphocytes.

Authors:  H Hamaguchi; M Yamada; M Shibasaki; R Mukai; T Yabe; I Kondo
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

10.  Estimation of genetic variability in natural populations of Drosophila simulans by two-dimensional and starch gel electrophoresis.

Authors:  S Ohnishi; A J Leigh Brown; R A Voelker; C H Langley
Journal:  Genetics       Date:  1982-01       Impact factor: 4.562
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